Cross-regulation between cytokine and microRNA pathways in T cells

© 2015 WILEY-VCH Verlag GmbH & Co. KGaA, WeinheimmicroRNA (miRNA) mediated regulation of protein expression has emerged as an important mechanism in T-cell physiology, from development and survival to activation, proliferation, and differentiation. One of the major classes of proteins involved in these processes are cytokines, which are both key input signals and major products of T-cell function. Here, we summarize the current data on the molecular cross-talk between cytokines and miRNAs: how cytokines regulate miRNA expression, and how specific miRNAs control cytokine production in T cells. We also describe the inflammatory consequences of deregulating the miRNA/cytokine axis in mice and humans. We believe this topical area will have key implications for immune modulation and treatment of autoimmune pathology.The study was funded by the European Research Council (StG_260352 [to B.S.-S.]). T.A. received a PhD fellowship from Fundação para a Ciência e a Tecnologia (PD/BD/52231/2013).