Glucose utilization increases in tumors, a metabolic process that is observed clinically by 18F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET). However, is increased glucose uptake important for tumor cells, and which transporters are implicated in vivo? In a genetically-engineered mouse model of lung adenocarcinoma, we show that the deletion of only one highly expressed glucose transporter, Glut1 or Glut3, in cancer cells does not impair tumor growth, whereas their combined loss diminishes tumor development. 18F-FDG-PET analyses of tumors demonstrate that Glut1 and Glut3 loss decreases glucose uptake, which is mainly dependent on Glut1. Using 13C-glucose tracing with correlated nanoscale secondary ion mass spectrometry (Nano...
Tumor growth causes cancer cells to become hypoxic. A hypoxic condition is a hallmark of cancer. Met...
Background: Due to proliferation and increased metabolism, cancer cells have high glucose requiremen...
Background: Malignant melanoma is the most aggressive of skin cancers and the 19th most common cance...
Glucose utilization increases in tumors, a metabolic process that is observed clinically by F-18-flu...
Glucose utilization increases in tumors, a metabolic process that is observed clinically by <sup&...
Lung cancers represent the leading cause of cancer-related deaths worldwide. These pulmonary cancers...
Background: Alterations in glucose metabolism and epithelial-mesenchymal transition (EMT) constitut...
Solute carriers of the glucose transporter (GLUT) family mediate the first step for cellular glucose...
BACKGROUND: Alterations in glucose metabolism and epithelial-mesenchymal transition (EMT) constitute...
While altered metabolism is a well-established tumor cell trait, the specifics of metabolic rewiring...
Tumor cells exhibit an altered metabolism characterized by elevated aerobic glycolysis and lactate s...
Neutrophils are the most abundant circulating leucocytes and are essential for innate immunity. In c...
Although overexpression of GLUT-1 glucose transporter has al ready been reported in human cancers, t...
Glucose is a major metabolic substrate required for cancer cell survival and growth. It is mainly im...
Neutrophils are the most abundant circulating leucocytes and are essential for innate immunity. In c...
Tumor growth causes cancer cells to become hypoxic. A hypoxic condition is a hallmark of cancer. Met...
Background: Due to proliferation and increased metabolism, cancer cells have high glucose requiremen...
Background: Malignant melanoma is the most aggressive of skin cancers and the 19th most common cance...
Glucose utilization increases in tumors, a metabolic process that is observed clinically by F-18-flu...
Glucose utilization increases in tumors, a metabolic process that is observed clinically by <sup&...
Lung cancers represent the leading cause of cancer-related deaths worldwide. These pulmonary cancers...
Background: Alterations in glucose metabolism and epithelial-mesenchymal transition (EMT) constitut...
Solute carriers of the glucose transporter (GLUT) family mediate the first step for cellular glucose...
BACKGROUND: Alterations in glucose metabolism and epithelial-mesenchymal transition (EMT) constitute...
While altered metabolism is a well-established tumor cell trait, the specifics of metabolic rewiring...
Tumor cells exhibit an altered metabolism characterized by elevated aerobic glycolysis and lactate s...
Neutrophils are the most abundant circulating leucocytes and are essential for innate immunity. In c...
Although overexpression of GLUT-1 glucose transporter has al ready been reported in human cancers, t...
Glucose is a major metabolic substrate required for cancer cell survival and growth. It is mainly im...
Neutrophils are the most abundant circulating leucocytes and are essential for innate immunity. In c...
Tumor growth causes cancer cells to become hypoxic. A hypoxic condition is a hallmark of cancer. Met...
Background: Due to proliferation and increased metabolism, cancer cells have high glucose requiremen...
Background: Malignant melanoma is the most aggressive of skin cancers and the 19th most common cance...