Add to ORKGThesis (Ph.D.)--University of Washington, 2021Chapter 1 contains a GWAS of QRS duration, a measure of ventricular depolarization and conduction, in 15,124 Hispanic/Latino individuals from four studies. We identified six loci associated with QRS (P<5x10-8), including two novel loci: MYOCD, a nuclear protein expressed in the heart, and SYT1, an integral membrane protein. Chapter 2 demonstrates the strong association of a genetic risk score (GRS) with ischemic stroke in European-ancestry participants with atrial fibrillation from the UK Biobank study (n=21,185). The GRS was independent of clinical risk factors. Including the GRS in clinical risk models may better identify individuals who could benefit from anticoagulation. Chapter 3 uses the e...
BACKGROUND: Atrial fibrillation (AF) has a substantial genetic basis. Identification of individuals ...
Cardiovascular disease is a major health concern affecting over 80,000,000 people in the U.S. alone....
Abstract: Coronary Heart Disease (CHD) is the number one cause of death in the current world. Since ...
The QT interval is a heritable electrocardiographic measure associated with arrhythmia risk when pro...
BackgroundThe electrocardiographically quantified QRS duration measures ventricular depolarization a...
The QT interval is an electrocardiographic measure representing the sum of ventricular depolarizatio...
Objective: We sought to assess whether genetic risk factors for atrial fibrillation (AF) can explain...
BACKGROUND: Atrial fibrillation (AF) has a substantial genetic basis. Identification of individuals ...
Cardiovascular disease is a major health concern affecting over 80,000,000 people in the U.S. alone....
Abstract: Coronary Heart Disease (CHD) is the number one cause of death in the current world. Since ...
The QT interval is a heritable electrocardiographic measure associated with arrhythmia risk when pro...
BackgroundThe electrocardiographically quantified QRS duration measures ventricular depolarization a...
The QT interval is an electrocardiographic measure representing the sum of ventricular depolarizatio...
Objective: We sought to assess whether genetic risk factors for atrial fibrillation (AF) can explain...
BACKGROUND: Atrial fibrillation (AF) has a substantial genetic basis. Identification of individuals ...
Cardiovascular disease is a major health concern affecting over 80,000,000 people in the U.S. alone....
Abstract: Coronary Heart Disease (CHD) is the number one cause of death in the current world. Since ...