Since the early 1990s, persistently low fertility in Mediterranean countries has attracted the interest of empirical research aimed at identifying factors associated with demographic change in what were traditionally high-fertility contexts. Most of these studies have been carried out at the national scale, while spatial analyses of sub-national patterns remain mostly absent. The present study aims to fill this gap, investigating the spatio-temporal changes in local fertility in Spanish municipalities over a 16-year period that covers consecutive waves of economic expansion (2002–2009) and recession (2010–2017). The analytical framework is grounded on descriptive statistics, spatial statistics (that is, Global Moran’s I and Local Indicators...