Urban expansion in advanced countries is the result of inherent transformations in settlement forms and socioeconomic functions leading to new metropolitan configurations. Assessing latent shifts from mono-centric structures to more fragmented, low-density and spatially-decentralized models was complicated by emerging processes of urban sprawl. In these regards, the present study proposes an original approach to the analysis of metropolitan configurations using a Geographically Weighted Regression (GWR) to investigate changes in the spatial distribution of specific urban functions over time. This framework was applied to long-term (1920–2010) evolution of three functions (population density, building density and per cent share of built-up a...