Effect of GLP-1 on liver metabolism in experiment

1 Summary GLP-1 (glucagon-like peptide-1) is a peptide hormone belonging to the group of incretins that is secreted postprandially from enteroendocrine L-cells. Number of studies described its effects to lower blood glucose level and to positively affect the B-cells of the islets of Langerhans (reducing apoptosis and accelerating their differentiation). The relationship of GLP-1 to liver cells is intensively studied. Studies described that GLP-1, its analogues or inhibition of dipeptidyl peptidase-4 have a wide range of effects in the liver. For our work was crucial that effects on lipid and saccharide metabolism in the liver were described, as well as modulation of processes related to endoplasmic reticulum stress, oxidative stress and formation of inflammatory mediators. These processes play an essential role in both: pathological conditions (eg. liver diseases NAFLD/NASH) and in the process of liver regeneration. Works describing the potential effect of incretin-based therapies in the treatment of liver diseases (especially NAFLD and NASH) were available prior to the start of our work. In contrast, results of studies on the effect of GLP-1 on the process of liver regeneration and proliferation and apoptosis of hepatocytes were very limited in the literature. The aim of our work was to elucidate the..