We identify amino acid variants within dominant SARS-CoV-2 T cell epitopes by interrogating global sequence data. Several variants within nucleocapsid and ORF3a epitopes have arisen independently in multiple lineages and result in loss of recognition by epitope-specific T cells assessed by IFN-γ and cytotoxic killing assays. Complete loss of T cell responsiveness was seen due to Q213K in the A∗01:01-restricted CD8+ ORF3a epitope FTSDYYQLY207-215; due to P13L, P13S, and P13T in the B∗27:05-restricted CD8+ nucleocapsid epitope QRNAPRITF9-17; and due to T362I and P365S in the A∗03:01/A∗11:01-restricted CD8+ nucleocapsid epitope KTFPPTEPK361-369. CD8+ T cell lines unable to recognize variant epitopes have diverse T cell receptor repertoires. Th...
T cells are involved in control of SARS-CoV-2 infection. To establish the patterns of immunodominanc...
T cells are involved in control of SARS-CoV-2 infection. To establish the patterns of immunodominanc...
The COVID-19 pandemic caused by SARS-CoV-2 is a continuous challenge worldwide, and there is an urge...
We identify amino acid variants within dominant SARS-CoV-2 T cell epitopes by interrogating glo...
We identify amino acid variants within dominant SARS-CoV-2 T cell epitopes by interrogating global s...
We identify amino acid variants within dominant SARS-CoV-2 T cell epitopes by interrogating global s...
We identify amino acid variants within dominant SARS-CoV-2 T cell epitopes by interrogating global s...
We identify amino acid variants within dominant SARS-CoV-2 T cell epitopes by interrogating global s...
Summary: Cellular immunity is important in determining the disease severity of COVID-19 patients. Ho...
CD4+ T cells are essential for protection against viruses, including SARS-CoV-2. The sensitivity of ...
Memory SARS-CoV-2-specific CD8+ T cell responses induced upon infection or COVID-19 vaccination have...
The emergence of SARS-CoV-2 variants with evidence of antibody escape highlight the importance of ad...
CD8 T cell immunity to SARS-CoV-2 has been implicated in COVID-19 severity and virus control. Here,...
The ongoing pandemic of SARS-CoV-2 has brought tremendous crisis on global health care systems and i...
Supplementary data for the Cell Systems manuscript 'The mutational landscape of SARS-CoV-2 variants ...
T cells are involved in control of SARS-CoV-2 infection. To establish the patterns of immunodominanc...
T cells are involved in control of SARS-CoV-2 infection. To establish the patterns of immunodominanc...
The COVID-19 pandemic caused by SARS-CoV-2 is a continuous challenge worldwide, and there is an urge...
We identify amino acid variants within dominant SARS-CoV-2 T cell epitopes by interrogating glo...
We identify amino acid variants within dominant SARS-CoV-2 T cell epitopes by interrogating global s...
We identify amino acid variants within dominant SARS-CoV-2 T cell epitopes by interrogating global s...
We identify amino acid variants within dominant SARS-CoV-2 T cell epitopes by interrogating global s...
We identify amino acid variants within dominant SARS-CoV-2 T cell epitopes by interrogating global s...
Summary: Cellular immunity is important in determining the disease severity of COVID-19 patients. Ho...
CD4+ T cells are essential for protection against viruses, including SARS-CoV-2. The sensitivity of ...
Memory SARS-CoV-2-specific CD8+ T cell responses induced upon infection or COVID-19 vaccination have...
The emergence of SARS-CoV-2 variants with evidence of antibody escape highlight the importance of ad...
CD8 T cell immunity to SARS-CoV-2 has been implicated in COVID-19 severity and virus control. Here,...
The ongoing pandemic of SARS-CoV-2 has brought tremendous crisis on global health care systems and i...
Supplementary data for the Cell Systems manuscript 'The mutational landscape of SARS-CoV-2 variants ...
T cells are involved in control of SARS-CoV-2 infection. To establish the patterns of immunodominanc...
T cells are involved in control of SARS-CoV-2 infection. To establish the patterns of immunodominanc...
The COVID-19 pandemic caused by SARS-CoV-2 is a continuous challenge worldwide, and there is an urge...