AbstractCirculating tumor DNA (ctDNA) in blood plasma is present at very low concentrations compared to cell-free DNA (cfDNA) of non-tumor origin. To enhance ctDNA detection, recent studies have been focused on understanding the non-random fragmentation pattern of cfDNA. These studies have investigated fragment sizes, genomic position of fragment end points, and fragment end motifs. Although these features have been described and shown to be aberrant in cancer patients, there is a lack of understanding of how the individual and integrated analysis of these features enrich ctDNA fraction and enhance ctDNA detection. Using whole genome sequencing and copy number analysis of plasma samples from 5 high grade serious ovarian cancer patients, we ...
In patients with early-stage cancer, ctDNA detection rates can be low due to the presence of few or ...
Circulating tumor-derived DNA (ctDNA) can be used to monitor cancer dynamics noninvasively. Detectio...
Circulating tumour DNA (ctDNA) is comprised of cell-free DNA (cfDNA) fragments released into bodily ...
Circulating tumor DNA (ctDNA) in blood plasma is present at very low concentrations compared to cell...
Existing methods to improve detection of circulating tumor DNA (ctDNA) have focused on genomic alter...
Existing methods to improve detection of circulating tumor DNA (ctDNA) have focused on genomic alter...
Existing methods to improve detection of circulating tumor DNA (ctDNA) have focused on genomic alter...
Background: Recent advances in the study and clinical applications of circulating tumor DNA (ctDNA) ...
Cancer cells release nucleic acids, freely or associated with other structures such as vesicles into...
Circulating tumor DNA (ctDNA) in plasma has been used as a biomarker for cancer detection and outcom...
Background: Circulating DNA (ctDNA) is acknowledged as a potential diagnostic tool for various cance...
BACKGROUND: Circulating DNA (ctDNA) is acknowledged as a potential diagnostic tool for various cance...
Circulating DNA (ctDNA) is acknowledged as a potential diagnostic tool for various cancers including...
Circulating tumor DNA (ctDNA) analysis has become a valuable tool for the investigation of cancer bi...
Molecular information obtained from cancer patients' blood is an emerging and powerful research tool...
In patients with early-stage cancer, ctDNA detection rates can be low due to the presence of few or ...
Circulating tumor-derived DNA (ctDNA) can be used to monitor cancer dynamics noninvasively. Detectio...
Circulating tumour DNA (ctDNA) is comprised of cell-free DNA (cfDNA) fragments released into bodily ...
Circulating tumor DNA (ctDNA) in blood plasma is present at very low concentrations compared to cell...
Existing methods to improve detection of circulating tumor DNA (ctDNA) have focused on genomic alter...
Existing methods to improve detection of circulating tumor DNA (ctDNA) have focused on genomic alter...
Existing methods to improve detection of circulating tumor DNA (ctDNA) have focused on genomic alter...
Background: Recent advances in the study and clinical applications of circulating tumor DNA (ctDNA) ...
Cancer cells release nucleic acids, freely or associated with other structures such as vesicles into...
Circulating tumor DNA (ctDNA) in plasma has been used as a biomarker for cancer detection and outcom...
Background: Circulating DNA (ctDNA) is acknowledged as a potential diagnostic tool for various cance...
BACKGROUND: Circulating DNA (ctDNA) is acknowledged as a potential diagnostic tool for various cance...
Circulating DNA (ctDNA) is acknowledged as a potential diagnostic tool for various cancers including...
Circulating tumor DNA (ctDNA) analysis has become a valuable tool for the investigation of cancer bi...
Molecular information obtained from cancer patients' blood is an emerging and powerful research tool...
In patients with early-stage cancer, ctDNA detection rates can be low due to the presence of few or ...
Circulating tumor-derived DNA (ctDNA) can be used to monitor cancer dynamics noninvasively. Detectio...
Circulating tumour DNA (ctDNA) is comprised of cell-free DNA (cfDNA) fragments released into bodily ...