Expression levels of most genes are proportional to cell volumes, although some genes exhibit nonlinear scaling of expression levels with cell volume. Here the authors provide a model that reveals nonlinear scaling is a direct consequence of heterogeneous recruitment abilities of promoters to RNA polymerases
The process of transcription initiation and elongation are primary points of control in the regulati...
(A) Transcription machinery (TM) binds with high affinity to the genes of size-independent proteins ...
International audienceThe aim of this paper is to analyze the dynamical behavior of biological model...
Cell size varies during the cell cycle and in response to external stimuli. This requires the tight ...
In this paper we study an important global regulation mechanism of transcription of biological cells...
Synthetic biology uses modeling to facilitate the design of new genetic constructions. In particular...
Studies in Escherichia coli using in vivo single-RNA detection and time-lapse confocal microscopy sh...
International audienceLive-cell imaging has revealed unexpected features of gene expression. Here us...
To understand the full breadth of the physiological implications of random fluctuations, of crucial ...
Live-cell imaging has revealed unexpected features of gene expression. Here using improved single-mo...
The proteins associated with gene regulation are often shared between multiple pathways simultaneous...
Noise in the expression of a gene produces fluctuations in the concentration of the gene product. Th...
Gene expression programs in living cells are highly dynamic due to spatiotemporal molecular signalin...
Varied abundance of gene expression machineries, such as RNA polymerase (RNAP) or ribosome, comprise...
Human cells are dynamic: they grow, replicate their genetic information (DNA), and divide. Clonal po...
The process of transcription initiation and elongation are primary points of control in the regulati...
(A) Transcription machinery (TM) binds with high affinity to the genes of size-independent proteins ...
International audienceThe aim of this paper is to analyze the dynamical behavior of biological model...
Cell size varies during the cell cycle and in response to external stimuli. This requires the tight ...
In this paper we study an important global regulation mechanism of transcription of biological cells...
Synthetic biology uses modeling to facilitate the design of new genetic constructions. In particular...
Studies in Escherichia coli using in vivo single-RNA detection and time-lapse confocal microscopy sh...
International audienceLive-cell imaging has revealed unexpected features of gene expression. Here us...
To understand the full breadth of the physiological implications of random fluctuations, of crucial ...
Live-cell imaging has revealed unexpected features of gene expression. Here using improved single-mo...
The proteins associated with gene regulation are often shared between multiple pathways simultaneous...
Noise in the expression of a gene produces fluctuations in the concentration of the gene product. Th...
Gene expression programs in living cells are highly dynamic due to spatiotemporal molecular signalin...
Varied abundance of gene expression machineries, such as RNA polymerase (RNAP) or ribosome, comprise...
Human cells are dynamic: they grow, replicate their genetic information (DNA), and divide. Clonal po...
The process of transcription initiation and elongation are primary points of control in the regulati...
(A) Transcription machinery (TM) binds with high affinity to the genes of size-independent proteins ...
International audienceThe aim of this paper is to analyze the dynamical behavior of biological model...