Effect of Inhaled Xenon on Cardiac Function in Comatose Survivors of Out-of-Hospital Cardiac Arrest—A Substudy of the Xenon in Combination With Hypothermia After Cardiac Arrest Trial
- Antti Saraste, MD, PhD
- Haitham Ballo, MD
- Olli Arola, MD, PhD
- Ruut Laitio, MD, PhD
- Juhani Airaksinen, MD, PhD
- Marja Hynninen, MD, PhD
- Minna Bäcklund, MD, PhD
- Emmi Ylikoski, MD, PhD
- Johanna Wennervirta, MD, PhD
- Mikko Pietilä, MD, PhD
- Risto O. Roine, MD, PhD
- Veli-Pekka Harjola, MD, PhD
- Jussi Niiranen, MD, PhD
- Kirsi Korpi, MD, PhD
- Marjut Varpula, MD, PhD
- Harry Scheinin, MD, PhD
- Mervyn Maze, MB ChB
- Tero Vahlberg, MSc
- Timo Laitio, MD, PhD
- for the Xe-HYPOTHECA Study Group
- Sami Virtanen
- Riitta Parkkola
- Jani Saunavaara
- Juha Martola
- Heli Silvennoinen
- Marjaana Tiainen
- Juha Grönlund
- Outi Inkinen
- Päivi Silvasti
- Eija Nukarinen
- Klaus T. Olkkola
DOIAbstract
OBJECTIVES:. This explorative substudy aimed at determining the effect of inhaled xenon on left ventricular function by echocardiography in comatose survivors of out-of-hospital cardiac arrest. DESIGN:. A randomized two-group single-blinded phase 2 clinical drug trial. SETTING:. A multipurpose ICU in two university hospitals. PATIENTS:. Of the 110 randomized comatose survivors after out-of-hospital cardiac arrest with a shockable rhythm in the xenon in combination with hypothermia after cardiac arrest trial, 38 patients (24–76 yr old) with complete echocardiography were included in this study. INTERVENTIONS:. Patients were randomized to receive either inhaled xenon combined with hypothermia (33°C) for 24 hours or hypothermia treatment alone...