Identification of Aggravation-Predicting Gene Polymorphisms in Coronavirus Disease 2019 Patients Using a Candidate Gene Approach Associated With Multiple Phase Pathogenesis: A Study in a Japanese City of 1 Million People
- Naoki Tanimine, MD, PhD
- Daisuke Takei, MD
- Naohumi Tsukiyama, MD
- Hisaaki Yoshinaka, MD
- Yuki Takemoto, MD
- Yuka Tanaka, PhD
- Tsuyoshi Kobayashi, MD, PhD
- Kazuaki Tanabe, MD, PhD
- Nobuhisa Ishikawa, MD, PhD
- Yoshihiro Kitahara, MD, PhD
- Mafumi Okimoto, MD
- Nobuaki Shime, MD, PhD
- Hiroki Ohge, MD, PhD
- Aya Sugiyama, MD, PhD
- Tomoyuki Akita, PhD
- Junko Tanaka, PhD
- Hideki Ohdan, MD, PhD
DOIAbstract
IMPORTANCE:. The pathology caused by the coronavirus disease 2019 is mediated by host-mediated lung inflammation, driving severity, and mortality. Polymorphisms in genes encoding host inflammation and immune-related molecules may be associated with the development of serious pathologies, and identifying such gene polymorphisms may lead to the identification of therapeutic targets. OBJECTIVES:. We attempted to identify aggravation-predicting gene polymorphisms. DESIGN:. We use a candidate gene approach associated with multiple phase pathogenesis in coronavirus disease 2019 patients among a cohort in Hiroshima, a city with a population of 1 million, in Japan. DNA samples from the study populations were genotyped for 34 functional polymorphism...
Add to ORKG