B-cell receptor (BCR)-mediated antigen internalization and presentation are essential for humoral memory immune responses. Antigen encountered by B-cells is often tightly associated with the surface of pathogens and/or antigen-presenting cells. Internalization of such antigens requires myosin-mediated traction forces and extracellular release of lysosomal enzymes, but the mechanism triggering lysosomal exocytosis is unknown. Here, we show that BCR-mediated recognition of antigen tethered to beads, to planar lipid-bilayers or expressed on cell surfaces causes localized plasma membrane (PM) permeabilization, a process that requires BCR signaling and non-muscle myosin II activity. B-cell permeabilization triggers PM repair responses involving ...
AbstractAntigen binding to the B cell receptor (BCR) induces receptor clustering, cell spreading, an...
The integrin LFA-1 and its ligand ICAM-1 mediate B cell adhesion, but their role in membrane-bound a...
The B cell antigen receptor (BCR) consists of membrane-bound immunoglobulin (mIg), which binds extra...
In order for humoral immune responses to develop, B cells must be able to bind and internalize antig...
The B cell antigen receptor (BCR) consists of membrane-bound immunoglobulin (mIg), which binds extra...
Engagement of the B cell receptor (BCR) by surface-tethered antigens (Ag) leads to formation of a sy...
SummaryEngagement of the B cell receptor (BCR) by surface-tethered antigens (Ag) leads to formation ...
Antigen recognition by B cells results in their activation followed by specific antibody production...
B cells are key mediators of humoral immunity and rely on signals initiated by the B cell receptor (...
B cells are responsible for the humoral responses of the adaptive immune system. B cells also act as...
The activation of B cells, a type of lymphocytes whose main function is to produce antibodies durin...
Our body is under constant attack by pathogens such as viruses or bacteria. The immune system has ev...
The B cell antigen receptors (BCRs) play an important role in the clonal selection of B cells and th...
AbstractThe integrin LFA-1 and its ligand ICAM-1 mediate B cell adhesion, but their role in membrane...
SummaryDendritic cells process internalized antigens to present degradative products on MHC for TCR ...
AbstractAntigen binding to the B cell receptor (BCR) induces receptor clustering, cell spreading, an...
The integrin LFA-1 and its ligand ICAM-1 mediate B cell adhesion, but their role in membrane-bound a...
The B cell antigen receptor (BCR) consists of membrane-bound immunoglobulin (mIg), which binds extra...
In order for humoral immune responses to develop, B cells must be able to bind and internalize antig...
The B cell antigen receptor (BCR) consists of membrane-bound immunoglobulin (mIg), which binds extra...
Engagement of the B cell receptor (BCR) by surface-tethered antigens (Ag) leads to formation of a sy...
SummaryEngagement of the B cell receptor (BCR) by surface-tethered antigens (Ag) leads to formation ...
Antigen recognition by B cells results in their activation followed by specific antibody production...
B cells are key mediators of humoral immunity and rely on signals initiated by the B cell receptor (...
B cells are responsible for the humoral responses of the adaptive immune system. B cells also act as...
The activation of B cells, a type of lymphocytes whose main function is to produce antibodies durin...
Our body is under constant attack by pathogens such as viruses or bacteria. The immune system has ev...
The B cell antigen receptors (BCRs) play an important role in the clonal selection of B cells and th...
AbstractThe integrin LFA-1 and its ligand ICAM-1 mediate B cell adhesion, but their role in membrane...
SummaryDendritic cells process internalized antigens to present degradative products on MHC for TCR ...
AbstractAntigen binding to the B cell receptor (BCR) induces receptor clustering, cell spreading, an...
The integrin LFA-1 and its ligand ICAM-1 mediate B cell adhesion, but their role in membrane-bound a...
The B cell antigen receptor (BCR) consists of membrane-bound immunoglobulin (mIg), which binds extra...