ABSTRACT Members of the genus Mycobacterium are the most prevalent cause of infectious diseases. Mycobacteria have a complex cell envelope containing a peptidoglycan layer and an additional arabinogalactan polymer to which a mycolic acid bilayer is linked; this complex, multilayered cell wall composition (mAGP) is conserved among all CMN group bacteria. The arabinogalactan and mycolic acid synthesis pathways constitute effective drug targets for tuberculosis treatment. Ethambutol (EMB), a classical antituberculosis drug, inhibits the synthesis of the arabinose polymer. Although EMB acts bacteriostatically, its underlying molecular mechanism remains unclear. Here, we used Corynebacterium glutamicum and Mycobacterium phlei as model organisms ...
Rifampicin, pyrazinamide, streptomycin, and ethambutol, in addition to isoniazid, are frequently use...
Inhibition of Mycobacterium tuberculosis (Mtb) cell wall assembly is an established strategy for ant...
The cell wall mycolyl-arabinogalactan-peptidoglycan complex is essential in mycobacterial species, s...
Members of the genus Mycobacterium are the most prevalent cause of infectious diseases. Mycobacteria...
Radmacher E, Stansen KC, Besra GS, et al. Ethambutol, a cell wall inhibitor of Mycobacterium tubercu...
The cell wall of Mycobacterium tuberculosis has a complex ultrastructure that consists of mycolic ac...
The cell wall of Mycobacterium tuberculosis has a complex ultrastructure that consists of mycolic ac...
Ethambutol (EMB), a frontline antituberculous drug, targets the mycobacterial cell wall, a unique st...
AbstractObjective/background: Cell wall-deficient bacterial forms (L-forms) may occur along with res...
Arabinofuranosyltransferase enzymes, such as EmbA, EmbB, and AftA, play pivotal roles in the biosynt...
in spite of effective antibiotics to treat TB (tuberculosis) since the early 1960s, we enter the new...
The arabinan-containing polysaccharides, arabinogalactan (AG) and lipoarabinomannan (LAM), are key c...
Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis (TB), is recognized as a glo...
Tuberculosis (TB) remains a major public health issue worldwide. Global TB control efforts are signi...
The cell wall mycolyl-arabinogalactan–peptidoglycan complex is essential in mycobacterial species, s...
Rifampicin, pyrazinamide, streptomycin, and ethambutol, in addition to isoniazid, are frequently use...
Inhibition of Mycobacterium tuberculosis (Mtb) cell wall assembly is an established strategy for ant...
The cell wall mycolyl-arabinogalactan-peptidoglycan complex is essential in mycobacterial species, s...
Members of the genus Mycobacterium are the most prevalent cause of infectious diseases. Mycobacteria...
Radmacher E, Stansen KC, Besra GS, et al. Ethambutol, a cell wall inhibitor of Mycobacterium tubercu...
The cell wall of Mycobacterium tuberculosis has a complex ultrastructure that consists of mycolic ac...
The cell wall of Mycobacterium tuberculosis has a complex ultrastructure that consists of mycolic ac...
Ethambutol (EMB), a frontline antituberculous drug, targets the mycobacterial cell wall, a unique st...
AbstractObjective/background: Cell wall-deficient bacterial forms (L-forms) may occur along with res...
Arabinofuranosyltransferase enzymes, such as EmbA, EmbB, and AftA, play pivotal roles in the biosynt...
in spite of effective antibiotics to treat TB (tuberculosis) since the early 1960s, we enter the new...
The arabinan-containing polysaccharides, arabinogalactan (AG) and lipoarabinomannan (LAM), are key c...
Mycobacterium tuberculosis (Mtb), the etiological agent of tuberculosis (TB), is recognized as a glo...
Tuberculosis (TB) remains a major public health issue worldwide. Global TB control efforts are signi...
The cell wall mycolyl-arabinogalactan–peptidoglycan complex is essential in mycobacterial species, s...
Rifampicin, pyrazinamide, streptomycin, and ethambutol, in addition to isoniazid, are frequently use...
Inhibition of Mycobacterium tuberculosis (Mtb) cell wall assembly is an established strategy for ant...
The cell wall mycolyl-arabinogalactan-peptidoglycan complex is essential in mycobacterial species, s...