ABSTRACT The metabolic pathways of central carbon metabolism, glycolysis and oxidative phosphorylation (OXPHOS), are important host factors that determine the outcome of viral infections and can be manipulated by some viruses to favor infection. However, mechanisms of metabolic modulation and their effects on viral replication vary widely. Herein, we present the first metabolomics and energetic profiling of norovirus-infected cells, which revealed increases in glycolysis, OXPHOS, and the pentose phosphate pathway (PPP) during murine norovirus (MNV) infection. Inhibiting glycolysis with 2-deoxyglucose (2DG) in macrophages revealed that glycolysis is an important factor for optimal MNV infection, while inhibiting the PPP and OXPHOS showed a r...
Human norovirus (HuNoV) causes the majority of acute, non-bacterial endemic gastroenteritis worldwid...
Human norovirus infections are the most common cause of acute nonbacterial gastroenteritis in humans...
ABSTRACT Nitric oxide is a versatile and critical effector molecule that can modulate many cellular ...
ABSTRACT The metabolic pathways of central carbon metabolism, glycolysis and oxidative phosphorylati...
AbstractTo ensure optimal environments for their replication and spread, viruses have evolved to alt...
Thesis (Ph.D.)--University of Washington, 2014Viruses are dependent on the metabolic machinery of th...
ABSTRACT Glycolysis, a series of oxidative reactions used to metabolize glucose and provide energy t...
© 2016 Dr. Tanya Beth O'DonnellHuman Norovirus (HuNoV) belongs to the Caliciviridae family and is th...
Murine norovirus (MNV) infection results in a late translation shut-off, that is proposed to contrib...
Viruses are intracellular parasites that rely on host machinery to replicate and achieve a successfu...
Cancer cells and viruses reprogram cell metabolism towards increased nutrient uptakeand anabolism. U...
Coxsackievirus B3 (CVB3) is a leading cause of viral myocarditis, but no effective treatment strateg...
Human norovirus (HuNoV) is the leading cause of gastroenteritis worldwide. Despite the significant d...
SummaryVirus infections trigger metabolic changes in host cells that support the bioenergetic and bi...
Tumour cells exhibiting the Warburg effect rely mostly upon aerobic glycolysis for ATP production an...
Human norovirus (HuNoV) causes the majority of acute, non-bacterial endemic gastroenteritis worldwid...
Human norovirus infections are the most common cause of acute nonbacterial gastroenteritis in humans...
ABSTRACT Nitric oxide is a versatile and critical effector molecule that can modulate many cellular ...
ABSTRACT The metabolic pathways of central carbon metabolism, glycolysis and oxidative phosphorylati...
AbstractTo ensure optimal environments for their replication and spread, viruses have evolved to alt...
Thesis (Ph.D.)--University of Washington, 2014Viruses are dependent on the metabolic machinery of th...
ABSTRACT Glycolysis, a series of oxidative reactions used to metabolize glucose and provide energy t...
© 2016 Dr. Tanya Beth O'DonnellHuman Norovirus (HuNoV) belongs to the Caliciviridae family and is th...
Murine norovirus (MNV) infection results in a late translation shut-off, that is proposed to contrib...
Viruses are intracellular parasites that rely on host machinery to replicate and achieve a successfu...
Cancer cells and viruses reprogram cell metabolism towards increased nutrient uptakeand anabolism. U...
Coxsackievirus B3 (CVB3) is a leading cause of viral myocarditis, but no effective treatment strateg...
Human norovirus (HuNoV) is the leading cause of gastroenteritis worldwide. Despite the significant d...
SummaryVirus infections trigger metabolic changes in host cells that support the bioenergetic and bi...
Tumour cells exhibiting the Warburg effect rely mostly upon aerobic glycolysis for ATP production an...
Human norovirus (HuNoV) causes the majority of acute, non-bacterial endemic gastroenteritis worldwid...
Human norovirus infections are the most common cause of acute nonbacterial gastroenteritis in humans...
ABSTRACT Nitric oxide is a versatile and critical effector molecule that can modulate many cellular ...