Zfhx4 regulates endochondral ossification as the transcriptional platform of Osterix in mice
- Eriko Nakamura
- Kenji Hata
- Yoshifumi Takahata
- Hiroshi Kurosaka
- Makoto Abe
- Takaya Abe
- Miho Kihara
- Toshihisa Komori
- Sachi Kobayashi
- Tomohiko Murakami
- Toshihiro Inubushi
- Takashi Yamashiro
- Shiori Yamamoto
- Haruhiko Akiyama
- Makoto Kawaguchi
- Nobuo Sakata
- Riko Nishimura
Publication date
November 2021
DOI Publisher
Springer Science and Business Media LLC Journal
Communications BiologyAbstract
Nakamura et al. used expression studies to identify an enrichment of Zfhx4 in cartilage and revealed through global gene knock-down that it is required for proper endochondral ossification in mice. They further demonstrated a physical and genetic interaction between Zfhx4 and Osterix, which is of interest to the field of transcriptional regulation of mammalian endochondral ossification
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