Retinal pigment epithelium (RPE) serves critical functions in maintaining retinal homeostasis. An important function of RPE is to degrade the photoreceptor outer segment fragments daily to maintain photoreceptor function and longevity throughout life. An impairment of RPE functions such as metabolic regulation leads to the development of age-related macular degeneration (AMD) and inherited retinal degenerative diseases. As substrate recognition subunit of a ubiquitin ligase complex, suppressor of cytokine signaling 2 (SOCS2) specifically binds to the substrates for ubiquitination and negatively regulates growth hormone signaling. Herein, we explore the role of SOCS2 in the metabolic regulation of autophagy in the RPE cells. SOCS2 knockout m...
Recent work suggested that the activity of extracellular signal-regulated kinase 1/2 (ERK1/2) is inc...
Age-related macular degeneration (AMD) is a complex eye disease with many pathogenesis factors, incl...
Purpose: To investigate the mechanism by which resveratrol acts upon retinal pigment epithelial (RPE...
Age-related macular degeneration (AMD) is a multi-factorial disease that is the leading cause of irr...
Age-related macular degeneration (AMD) is characterized primarily by degeneration of the macular ret...
AbstractAs a signaling hub, p62/sequestosome plays important roles in cell signaling and degradation...
Age-related macular degeneration (AMD) is a leading cause of severe visual loss and irreversible bli...
Purpose: Dysfunctional autophagy in the retinal pigment epithelium (RPE) has been implicated as a th...
Autophagic dysregulation has been suggested in a broad range of neurodegenerative diseases including...
SummaryPhagocytosis and degradation of photoreceptor outer segments (POS) by retinal pigment epithel...
Age-related macular degeneration (AMD), the leading cause of blindness among the elderly, is without...
Non-exudative age-related macular degeneration (AMD) is mainly caused by the accumulation of lipofus...
AIM: To identify the effect and regulatory mechanism of amyloid β (Aβ) protein on retinal pigment ep...
Unchecked, chronic inflammation is a constitutive component of age-related diseases, including age-r...
Which pathogenic mechanisms underlie age-related macular degeneration (AMD)? Are they different for ...
Recent work suggested that the activity of extracellular signal-regulated kinase 1/2 (ERK1/2) is inc...
Age-related macular degeneration (AMD) is a complex eye disease with many pathogenesis factors, incl...
Purpose: To investigate the mechanism by which resveratrol acts upon retinal pigment epithelial (RPE...
Age-related macular degeneration (AMD) is a multi-factorial disease that is the leading cause of irr...
Age-related macular degeneration (AMD) is characterized primarily by degeneration of the macular ret...
AbstractAs a signaling hub, p62/sequestosome plays important roles in cell signaling and degradation...
Age-related macular degeneration (AMD) is a leading cause of severe visual loss and irreversible bli...
Purpose: Dysfunctional autophagy in the retinal pigment epithelium (RPE) has been implicated as a th...
Autophagic dysregulation has been suggested in a broad range of neurodegenerative diseases including...
SummaryPhagocytosis and degradation of photoreceptor outer segments (POS) by retinal pigment epithel...
Age-related macular degeneration (AMD), the leading cause of blindness among the elderly, is without...
Non-exudative age-related macular degeneration (AMD) is mainly caused by the accumulation of lipofus...
AIM: To identify the effect and regulatory mechanism of amyloid β (Aβ) protein on retinal pigment ep...
Unchecked, chronic inflammation is a constitutive component of age-related diseases, including age-r...
Which pathogenic mechanisms underlie age-related macular degeneration (AMD)? Are they different for ...
Recent work suggested that the activity of extracellular signal-regulated kinase 1/2 (ERK1/2) is inc...
Age-related macular degeneration (AMD) is a complex eye disease with many pathogenesis factors, incl...
Purpose: To investigate the mechanism by which resveratrol acts upon retinal pigment epithelial (RPE...