Within-host evolution of SARS-CoV-2 in an immunosuppressed COVID-19 patient as a source of immune escape variants
- Sebastian Weigang
- Jonas Fuchs
- Gert Zimmer
- Daniel Schnepf
- Lisa Kern
- Julius Beer
- Hendrik Luxenburger
- Jakob Ankerhold
- Valeria Falcone
- Janine Kemming
- Maike Hofmann
- Robert Thimme
- Christoph Neumann-Haefelin
- Svenja Ulferts
- Robert Grosse
- Daniel Hornuss
- Yakup Tanriver
- Siegbert Rieg
- Dirk Wagner
- Daniela Huzly
- Martin Schwemmle
- Marcus Panning
- Georg Kochs
Publication date
November 2021
DOI Publisher
Springer Science and Business Media LLC Journal
Nature CommunicationsAbstract
Here, in a longitudinal case study, Weigang et al. demonstrate that evolution of SARS-CoV-2 within a persistently infected immunosuppressed patient can result in the emergence of novel variants with reduced sensitivity to antibody neutralization
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