N 1-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism

Yanying Wang
Jing Wang
Xiaoyu Li
Xushen Xiong
Jianyi Wang
Ziheng Zhou
Xiaoxiao Zhu
Yang Gu
Dan Dominissini
Lei He
Yong Tian
Chengqi Yi
Zusen Fan

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Publication date

November 2021

DOI

10.1038/s41467-021-26718-6

Publisher

Springer Science and Business Media LLC

Journal

Nature Communications

Abstract

Metabolic adaptation has been reported to promote cancer, yet the underlying mechanisms are not clear. Here, the authors show that m1A methylation in tRNA regulates cholesterol metabolism in liver cancer stem cells and m1A inhibition decreases tumourigenesis in preclinical models of hepatocellular carcinoma

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N 1-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism

Abstract

Extracted data

N 1-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism

Abstract

Extracted data

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