ABSTRACT In the coronavirus disease 2019 (COVID-19) pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), more severe outcomes are reported in males than in females, including hospitalizations and deaths. Animal models can provide an opportunity to mechanistically interrogate causes of sex differences in the pathogenesis of SARS-CoV-2. Adult male and female golden Syrian hamsters (8 to 10 weeks of age) were inoculated intranasally with 105 50% tissue culture infective dose (TCID50) of SARS-CoV-2/USA-WA1/2020 and euthanized at several time points during the acute (i.e., virus actively replicating) and recovery (i.e., after the infectious virus has been cleared) phases of infection. There was no mortality, but i...
Coronavirus disease 2019 (COVID-19) exhibits a sex bias with males showing signs of more severe dise...
Shiu-Ju Yang,1 Ting-Chun Wei,1 Chih-Hao Hsu,1 Sin-Ni Ho,1 Chi-Yun Lai,2 Shiu-Feng Huang,2,3 Yih-Yuan...
In COVID-19, immune responses are key in determining disease severity. However, cellular mechanisms ...
Epidemiological studies of the COVID-19 patients have suggested the male bias in outcomes of lung il...
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has highlighted the im...
Pathogenic human coronaviruses (CoVs), such as the severe acute respiratory syndrome (SARS)-CoV and ...
[[abstract]]BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coro...
In late 2019, an outbreak of a severe respiratory disease caused by an emerging coronavirus, SARS-Co...
The Syrian hamster has proved useful in the evaluation of therapeutics and vaccines for severe acute...
AbstractSeveral small animal models have been developed for the study of severe acute respiratory sy...
Emergence of SARS-CoV-2 causing COVID-19 has resulted in hundreds of thousands of deaths. In search ...
Coronavirus disease 2019 (COVID-19) exhibits a sex bias with males showing signs of more severe dise...
We present a comprehensive analysis of SARS-CoV-2 infection and recovery using wild type C57BL/6 mic...
Men present more frequently with severe manifestations of coronavirus disease 2019 (COVID-19) and ar...
Small animal models are needed in order to evaluate the efficacy of candidate vaccines and antiviral...
Coronavirus disease 2019 (COVID-19) exhibits a sex bias with males showing signs of more severe dise...
Shiu-Ju Yang,1 Ting-Chun Wei,1 Chih-Hao Hsu,1 Sin-Ni Ho,1 Chi-Yun Lai,2 Shiu-Feng Huang,2,3 Yih-Yuan...
In COVID-19, immune responses are key in determining disease severity. However, cellular mechanisms ...
Epidemiological studies of the COVID-19 patients have suggested the male bias in outcomes of lung il...
The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has highlighted the im...
Pathogenic human coronaviruses (CoVs), such as the severe acute respiratory syndrome (SARS)-CoV and ...
[[abstract]]BACKGROUND: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coro...
In late 2019, an outbreak of a severe respiratory disease caused by an emerging coronavirus, SARS-Co...
The Syrian hamster has proved useful in the evaluation of therapeutics and vaccines for severe acute...
AbstractSeveral small animal models have been developed for the study of severe acute respiratory sy...
Emergence of SARS-CoV-2 causing COVID-19 has resulted in hundreds of thousands of deaths. In search ...
Coronavirus disease 2019 (COVID-19) exhibits a sex bias with males showing signs of more severe dise...
We present a comprehensive analysis of SARS-CoV-2 infection and recovery using wild type C57BL/6 mic...
Men present more frequently with severe manifestations of coronavirus disease 2019 (COVID-19) and ar...
Small animal models are needed in order to evaluate the efficacy of candidate vaccines and antiviral...
Coronavirus disease 2019 (COVID-19) exhibits a sex bias with males showing signs of more severe dise...
Shiu-Ju Yang,1 Ting-Chun Wei,1 Chih-Hao Hsu,1 Sin-Ni Ho,1 Chi-Yun Lai,2 Shiu-Feng Huang,2,3 Yih-Yuan...
In COVID-19, immune responses are key in determining disease severity. However, cellular mechanisms ...