Microenvironmental IL-6 inhibits anti-cancer immune responses generated by cytotoxic chemotherapy

Eric H. Bent
Luis R. Millán-Barea
Iris Zhuang
Daniel R. Goulet
Julia Fröse
Michael T. Hemann

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Publication date

October 2021

DOI

10.1038/s41467-021-26407-4

Publisher

Springer Science and Business Media LLC

Journal

Nature Communications

Abstract

Cytotoxic chemotherapy rarely generates durable anti-tumor immune responses. Here the authors show that tumor microenvironment-derived IL-6 promotes resistance to doxorubicin by suppressing CD8 T cell anti-tumor immune responses in a preclinical model of B-cell acute lymphoblastic leukemia

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Microenvironmental IL-6 inhibits anti-cancer immune responses generated by cytotoxic chemotherapy

Abstract

Extracted data

Microenvironmental IL-6 inhibits anti-cancer immune responses generated by cytotoxic chemotherapy

Abstract

Extracted data

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