Anti-Inflammatory Effects of Curcumin in the Inflammatory Diseases: Status, Limitations and Countermeasures

Ying Peng,1 Mingyue Ao,1 Baohua Dong,1 Yunxiu Jiang,1 Lingying Yu,1 Zhimin Chen,1 Changjiang Hu,1,2 Runchun Xu1 1State Key Laboratory of Southwestern Chinese Medicine Resources; Pharmacy College, Chengdu University of Traditional Chinese Medicine, Chengdu, People’s Republic of China; 2Neo-Green Pharmaceutical Co., Ltd., Chengdu, People’s Republic of ChinaCorrespondence: Zhimin Chen; Changjiang Hu Email chenzhimin@cdutcm.edu.cn; 654460129@qq.comAbstract: Curcumin is a natural compound with great potential for disease treatment. A large number of studies have proved that curcumin has a variety of biological activities, among which anti-inflammatory effect is a significant feature of it. Inflammation is a complex and pervasive physiological and pathological process. The physiological and pathological mechanisms of inflammatory bowel disease, psoriasis, atherosclerosis, COVID-19 and other research focus diseases are not clear yet, and they are considered to be related to inflammation. The anti-inflammatory effect of curcumin can effectively improve the symptoms of these diseases and is expected to be a candidate drug for the treatment of related diseases. This paper mainly reviews the anti-inflammatory effect of curcumin, the inflammatory pathological mechanism of related diseases, the regulatory effect of curcumin on these, and the latest research results on the improvement of curcumin pharmacokinetics. It is beneficial to the further study of curcumin and provides new ideas and insights for the development of curcumin anti-inflammatory preparations.Keywords: anti-inflammatory, osteoarthritis, psoriasis, atherosclerotic, pharmacokinetics, prodru