The Effect of Tarantula cubensis Extract on Gentamicin-Induced Acute Kidney Injury in Ovariectomized Rats

This study examined the effect of Tarantula cubensis extract (TCE) on gentamicin-induced acute kidney injury in ovariectomized rats. A total of 40 female Wistar albino rats were randomly divided equally into five groups: Control (C), ovariectomy (O), Tarantula cubensis (OT), gentamicin (OG), and gentamicin + Tarantula cubensis (OGT). All rats except those in the C were ovariectomized. Kidney damage was created with gentamicin for OG and OGT. The OT and OGT were treated with a single dose of TCE. Blood, sera, and kidney tissue were taken at necropsy for evaluation. Total leukocyte count was higher in the OT compared to the others (P=0.002). Significant increases were also determined in serum urea, creatinine, aspartate aminotransferase, and total protein levels in the OT, OG, and OGT compared to the C and O. The glutathione level was low in the serum and kidney tissue of the OG, and the malondialdehyde level was high compared to the others (P