Proprotein convertases subtilisin kexins are serine endoproteases, playing critical roles in the biological functions, including lipid, glucose, and bile acid metabolism, as well as cell proliferation, migration, and metastasis. Experimental studies have demonstrated the physiological functions of PCSKs and their association with diseases; however, studies on the evolutionary history and diversification of these proteins are missing. In the present research, a bioinformatics study was conducted on the molecular evolution of several PCSKs family members and gene loss events across placental mammalian. In order to detect evolutionary constraints and positive selection, the CodeML program of the PAML package was used. The results showed the po...
The proprotein convertase subtilisin/kexin (PCSK) is a serine endopeptidase family. PCSKs cleave ami...
The inactivation of ancestral protein-coding genes (gene loss) can be associated with phenotypic mod...
The group of receptor-interacting protein (RIP) kinases has seven members (RIPK1–7), with one homolo...
Abstract Background Subtilisin/kexin-like proprotein convertase (PCSK) enzymes have important regula...
Proprotein convertase subtilisin/kexin (PCSK) enzymes cleave and convert their immature substrates i...
BACKGROUND: The mitogen activated protein kinases (MAPK) family pathway is implicated in diverse cel...
The proprotein convertase subtilisin/kexins (PCSKs) are a serine endopeptidase family. PCSK members ...
At the genetic level, one of the fastest means to adapt to environmental cues is by gene duplication...
The mitogen activated protein kinases (MAPK) family pathway is implicated in diverse cellular proces...
The inactivation of ancestral protein-coding genes (gene loss) can be associated with phenotypic mod...
BackgroundCommon single nucleotide polymorphisms (SNPs) in proprotein convertase subtilisin/kexin ty...
The group of receptor-interacting protein (RIP) kinases has seven members (RIPK1–7), with one homolo...
Review on PCSK4 (proprotein convertase subtilisin/kexin type 4), with data on DNA, on the protein en...
The gene family of human kallikrein-related peptidases (KLKs) encodes proteins with diverse and plei...
Abstract: Phosphoenolpyruvate carboxykinase (PCK) is the key enzyme to initiate the gluconeogenic pa...
The proprotein convertase subtilisin/kexin (PCSK) is a serine endopeptidase family. PCSKs cleave ami...
The inactivation of ancestral protein-coding genes (gene loss) can be associated with phenotypic mod...
The group of receptor-interacting protein (RIP) kinases has seven members (RIPK1–7), with one homolo...
Abstract Background Subtilisin/kexin-like proprotein convertase (PCSK) enzymes have important regula...
Proprotein convertase subtilisin/kexin (PCSK) enzymes cleave and convert their immature substrates i...
BACKGROUND: The mitogen activated protein kinases (MAPK) family pathway is implicated in diverse cel...
The proprotein convertase subtilisin/kexins (PCSKs) are a serine endopeptidase family. PCSK members ...
At the genetic level, one of the fastest means to adapt to environmental cues is by gene duplication...
The mitogen activated protein kinases (MAPK) family pathway is implicated in diverse cellular proces...
The inactivation of ancestral protein-coding genes (gene loss) can be associated with phenotypic mod...
BackgroundCommon single nucleotide polymorphisms (SNPs) in proprotein convertase subtilisin/kexin ty...
The group of receptor-interacting protein (RIP) kinases has seven members (RIPK1–7), with one homolo...
Review on PCSK4 (proprotein convertase subtilisin/kexin type 4), with data on DNA, on the protein en...
The gene family of human kallikrein-related peptidases (KLKs) encodes proteins with diverse and plei...
Abstract: Phosphoenolpyruvate carboxykinase (PCK) is the key enzyme to initiate the gluconeogenic pa...
The proprotein convertase subtilisin/kexin (PCSK) is a serine endopeptidase family. PCSKs cleave ami...
The inactivation of ancestral protein-coding genes (gene loss) can be associated with phenotypic mod...
The group of receptor-interacting protein (RIP) kinases has seven members (RIPK1–7), with one homolo...