The identification of “trained immunity/tolerance” in myeloid cells has changed our perception of the performance of monocytes and macrophages during inflammatory and immune responses. Pemetrexed (PMX) and methotrexate (MTX) are blockers of the one-carbon metabolism (OCM) and commonly used therapeutic agents in cancer and rheumatoid arthritis (RA). We have previously showed that MTX promotes trained immunity in human macrophages. In the present manuscript, we have assessed the anti-inflammatory effects of PMX and MTX and found that OCM blockers alter the functional and gene expression profile of human macrophages and that OCM blockade reprograms macrophages towards a state of lipopolysaccharide (LPS) tolerance at the signaling and functiona...
Objective Rheumatoid arthritis (RA) is a systemic, immune-mediated inflammatory disease that ultimat...
Background: Methotrexate (MTX) is the fi rst line treatment of rheumatoid arthritis (RA), and methyla...
Methotrexate (MTX) is an immunosuppressant commonly used for the treatment of autoimmune diseases. R...
8p.-6 fig.OBJECTIVES: Methotrexate (MTX) is the anchor drug for treatment of rheumatoid arthritis...
This open label study examines whether methotrexate (MTX) treatment modulates ex vivo synthesis of i...
Methotrexate (MTX) is an antifolate drug used as a chemotherapeutic agent for acute lymphoblastic le...
Objectives Methotrexate (MTX) is an anchor drug for the treatment of rheumatoid arthritis (RA). Howe...
Objective To describe changes in immune parameters observed during long-term methotrexate (MTX) ther...
Objective. To evaluate the anti-arthritic effects of the new inflammation-targeted drug MTX-HSA and ...
The signalling receptor for LPS, CD14, is a key marker of, and facilitator for, pro-inflammatory mac...
Aims Premature cardiovascular events complicate chronic inflammatory conditions. Low-dose weekly met...
If misregulated, macrophage (M)T cell interactions can drive chronic inflammation thereby causing di...
Methotrexate (MTX) is a folate analogue antimetabolite widely used for the treatment of rheumatoid a...
Methotrexate (MTX) is recognized as the anchor drug in the algorithm treating chronic arthritis (RA,...
IntroductionMethotrexate (MTX) enters cells via the reduced folate carrier SLC19A1, suggesting that ...
Objective Rheumatoid arthritis (RA) is a systemic, immune-mediated inflammatory disease that ultimat...
Background: Methotrexate (MTX) is the fi rst line treatment of rheumatoid arthritis (RA), and methyla...
Methotrexate (MTX) is an immunosuppressant commonly used for the treatment of autoimmune diseases. R...
8p.-6 fig.OBJECTIVES: Methotrexate (MTX) is the anchor drug for treatment of rheumatoid arthritis...
This open label study examines whether methotrexate (MTX) treatment modulates ex vivo synthesis of i...
Methotrexate (MTX) is an antifolate drug used as a chemotherapeutic agent for acute lymphoblastic le...
Objectives Methotrexate (MTX) is an anchor drug for the treatment of rheumatoid arthritis (RA). Howe...
Objective To describe changes in immune parameters observed during long-term methotrexate (MTX) ther...
Objective. To evaluate the anti-arthritic effects of the new inflammation-targeted drug MTX-HSA and ...
The signalling receptor for LPS, CD14, is a key marker of, and facilitator for, pro-inflammatory mac...
Aims Premature cardiovascular events complicate chronic inflammatory conditions. Low-dose weekly met...
If misregulated, macrophage (M)T cell interactions can drive chronic inflammation thereby causing di...
Methotrexate (MTX) is a folate analogue antimetabolite widely used for the treatment of rheumatoid a...
Methotrexate (MTX) is recognized as the anchor drug in the algorithm treating chronic arthritis (RA,...
IntroductionMethotrexate (MTX) enters cells via the reduced folate carrier SLC19A1, suggesting that ...
Objective Rheumatoid arthritis (RA) is a systemic, immune-mediated inflammatory disease that ultimat...
Background: Methotrexate (MTX) is the fi rst line treatment of rheumatoid arthritis (RA), and methyla...
Methotrexate (MTX) is an immunosuppressant commonly used for the treatment of autoimmune diseases. R...