Bmal1 in the striatum influences alcohol intake in a sexually dimorphic manner
- Nuria de Zavalia
- Konrad Schoettner
- Jory A. Goldsmith
- Pavel Solis
- Sarah Ferraro
- Gabrielle Parent
- Shimon Amir
Publication date
October 2021
DOI Publisher
Springer Science and Business Media LLC Journal
Communications BiologyAbstract
In order to examine the role of the circadian clock driver Brain and Muscle ARNT-Like 1 (Bmal1) in alcohol consumption, de Zavalia et al assess the effects of (Bmal1) deletion in the mouse striatum on alcohol drinking behavior. They show that striatal Bmal1 and downstream effects on Period Circadian Regulator 2 (Per2) play a sex-dependent role on alcohol consumption propensity
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