Disturbances in the one-carbon metabolism are often indicated by altered levels of the endogenous amino acid homocysteine (HCys), which is additionally discussed to causally contribute to diverse pathologies. In the first part of the present review, we profoundly and critically discuss the metabolic role and pathomechanisms of HCys, as well as its potential impact on different human disorders. The use of adequate animal models can aid in unravelling the complex pathological processes underlying the role of hyperhomocysteinemia (HHCys). Therefore, in the second part, we systematically searched PubMed/Medline for animal studies regarding HHCys and focused on the potential impact on cognitive performance and decline. The majority of reviewed s...
Cognitive impairment is common in elderly people and represents clinical feature of neurodegenerativ...
Although homocysteine (Hcy) has been widely implicated in the etiology of various physical health im...
Background: Hyperhomocysteinemia is considered a possible contributor to the complex pathology of Al...
AbstractHomocystinuria is an inherited metabolic disease biochemically characterized by tissue accum...
Homocysteine, a metabolite from methionine breakdown, can have detrimental effects to multiple syste...
Homocysteine (Hcy) is a sulfur-containing non-proteinogenic amino acid derived in methionine metabol...
There is strong evidence that homocysteine is a risk factor not only for cerebrovascular diseases bu...
2siHomocysteine (Hcy) is a sulfur-containing amino acid that is generated during methionine metaboli...
Homocysteine (Hcy) is a sulfur-containing amino acid that is generated during methionine metabolism....
Elevated plasma levels of homocysteine (Hcy) are a risk factor for systemic vascular diseases, strok...
Homocysteine is a sulfur-containing amino acid, which is synthesized from the precursor methionine t...
Homocysteine (Hcy) is a thiol group containing the amino acid, which naturally occurs in all humans....
Homocysteine (Hcy); a sulfur-containing non-proteinogenic amino acid is generated as a metabolic int...
AbstractMild to moderate hyperhomocysteinemia is a risk factor for neurodegenerative diseases. Human...
Homocysteine, a metabolite from methionine breakdown, can have detrimental effects to multiple syste...
Cognitive impairment is common in elderly people and represents clinical feature of neurodegenerativ...
Although homocysteine (Hcy) has been widely implicated in the etiology of various physical health im...
Background: Hyperhomocysteinemia is considered a possible contributor to the complex pathology of Al...
AbstractHomocystinuria is an inherited metabolic disease biochemically characterized by tissue accum...
Homocysteine, a metabolite from methionine breakdown, can have detrimental effects to multiple syste...
Homocysteine (Hcy) is a sulfur-containing non-proteinogenic amino acid derived in methionine metabol...
There is strong evidence that homocysteine is a risk factor not only for cerebrovascular diseases bu...
2siHomocysteine (Hcy) is a sulfur-containing amino acid that is generated during methionine metaboli...
Homocysteine (Hcy) is a sulfur-containing amino acid that is generated during methionine metabolism....
Elevated plasma levels of homocysteine (Hcy) are a risk factor for systemic vascular diseases, strok...
Homocysteine is a sulfur-containing amino acid, which is synthesized from the precursor methionine t...
Homocysteine (Hcy) is a thiol group containing the amino acid, which naturally occurs in all humans....
Homocysteine (Hcy); a sulfur-containing non-proteinogenic amino acid is generated as a metabolic int...
AbstractMild to moderate hyperhomocysteinemia is a risk factor for neurodegenerative diseases. Human...
Homocysteine, a metabolite from methionine breakdown, can have detrimental effects to multiple syste...
Cognitive impairment is common in elderly people and represents clinical feature of neurodegenerativ...
Although homocysteine (Hcy) has been widely implicated in the etiology of various physical health im...
Background: Hyperhomocysteinemia is considered a possible contributor to the complex pathology of Al...