Raf kinase inhibitory protein (RKIP) is an essential regulator of the Ras/Raf-1/MEK/ERK signaling cascade and functions by directly interacting with the Raf-1 kinase. The abnormal expression of RKIP is linked with numerous diseases including cancers, Alzheimer’s and diabetic nephropathy. Interestingly, RKIP also plays an indispensable role as a tumor suppressor, thus making it an attractive therapeutic target. To date, only a few small molecules have been reported to modulate the activity of RKIP, and there is a need to explore additional scaffolds. In order to achieve this objective, a pharmacophore model was generated that explores the features of locostatin, the most potent RKIP modulator. Correspondingly, the developed model was subject...
Mammalian target of rapamycin (mTOR) is a PI3K-related serine/threonine protein kinase that function...
Background: CDK4/6 (Cyclin-dependent kinases 4/6) are the key promoters of cell cycle transition fro...
Mangrove secondary metabolites have many unique biological activities. We identified lead compounds ...
Raf kinase inhibitory protein (RKIP), also known as phoshaptidylethanolamine binding protein (PEBP),...
Raf kinase inhibitory protein (RKIP), also known as phoshaptidylethanolamine binding protein (PEBP),...
Raf Kinase Inhibitor Protein (RKIP) has been identified as a phosphatidylethanolamine-binding protei...
<p>Rho-associated protein kinases (ROCKs) are a member of the serine/threonine protein kinase family...
ABSTRACT: The present work is aimed to provide detail on the binding process between Raf kinase inhi...
Raf Kinase Inhibitory Protein (RKIP, also PEBP1), a member of the Phosphatidylethanolamine Binding P...
SummaryRaf kinase inhibitor protein (RKIP) is a modulator of cell signaling that functions as an end...
Each year in the United States, prostate cancer kills over 40,000 men, and over 200,000 new cases ar...
The p90 ribosomal protein S6 Kinase (RSK) family belongs to Ser/Thr protein kinases that includes fo...
The aim of this research was to screen the ZINC15 database to select lead compounds and drug candida...
Background and purpose: Aberrant signaling by oncogenic RAS proteins occurs in almost all human tumo...
The studies presented here were designed to test if Raf-1 kinase inhibitor protein (RKIP) plays a fu...
Mammalian target of rapamycin (mTOR) is a PI3K-related serine/threonine protein kinase that function...
Background: CDK4/6 (Cyclin-dependent kinases 4/6) are the key promoters of cell cycle transition fro...
Mangrove secondary metabolites have many unique biological activities. We identified lead compounds ...
Raf kinase inhibitory protein (RKIP), also known as phoshaptidylethanolamine binding protein (PEBP),...
Raf kinase inhibitory protein (RKIP), also known as phoshaptidylethanolamine binding protein (PEBP),...
Raf Kinase Inhibitor Protein (RKIP) has been identified as a phosphatidylethanolamine-binding protei...
<p>Rho-associated protein kinases (ROCKs) are a member of the serine/threonine protein kinase family...
ABSTRACT: The present work is aimed to provide detail on the binding process between Raf kinase inhi...
Raf Kinase Inhibitory Protein (RKIP, also PEBP1), a member of the Phosphatidylethanolamine Binding P...
SummaryRaf kinase inhibitor protein (RKIP) is a modulator of cell signaling that functions as an end...
Each year in the United States, prostate cancer kills over 40,000 men, and over 200,000 new cases ar...
The p90 ribosomal protein S6 Kinase (RSK) family belongs to Ser/Thr protein kinases that includes fo...
The aim of this research was to screen the ZINC15 database to select lead compounds and drug candida...
Background and purpose: Aberrant signaling by oncogenic RAS proteins occurs in almost all human tumo...
The studies presented here were designed to test if Raf-1 kinase inhibitor protein (RKIP) plays a fu...
Mammalian target of rapamycin (mTOR) is a PI3K-related serine/threonine protein kinase that function...
Background: CDK4/6 (Cyclin-dependent kinases 4/6) are the key promoters of cell cycle transition fro...
Mangrove secondary metabolites have many unique biological activities. We identified lead compounds ...