QUANTITATIVE REAL-TIME PCR (RT-QPCR) COMPARING THE RELATIVE EXPRESSION LEVELS OF GENE TRANSCRIPTS INVOLVED IN A CRYPTIC THREE-WAY TRANSLOCATION T(9;11;19): AN ORIGINAL CASE OF AN INFANT WITH DISMAL PROGNOSIS ACUTE LYMPHOBLASTIC LEUKEMIA
- GM Ferreira
- RRC Matos
- KC Monteso
- MM Rocha
- MT Bizarro
- C Meyer
- T Liehr
- E Abdelhay
- R Binato
- MLM Silva
DOIAbstract
Objectives: KMT2A gene aberrations are more frequent in infants less than one year (yr) of age, accounting for about 70% of acute lymphoblastic leukemia (ALL) patients, and about 30% are diagnosed with acute myeloid leukemia (AML). The most common abnormality found in these patients is the translocation t(11;19)(q23;p13.3), corresponding to 22% of KMT2A rearranged (KMT2A-r) positive cases. Related literature data shows that infants <1 yr with t(11;19)(q23;p13.3) present with up to 50% additional chromosomal changes. In this context, Meyer and coworkers (2007) showed that 25% of the patients with t(11;19)(q23;p13.3) and the KMT2A-MLLT1 fusion transcript presented three-way or more complex fusions, associated with a worse prognosis. In such c...
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