Metabolic derangement in polycystic kidney disease mouse models is ameliorated by mitochondrial-targeted antioxidants

Nastaran Daneshgar
Andrew W. Baguley
Peir-In Liang
Fei Wu
Yi Chu
Michael T. Kinter
Gloria A. Benavides
Michelle S. Johnson
Victor Darley-Usmar
Jianhua Zhang
Kung-Sik Chan
Dao-Fu Dai

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Publication date

October 2021

DOI

10.1038/s42003-021-02730-w

Publisher

Springer Science and Business Media LLC

Journal

Communications Biology

Abstract

Daneshgar et al. investigated the role of mitochondrial dysfunction in ADPKD and mitochondria protective agents as potential therapeutics. The authors reported decreased mitochondrial complex activity and downregulation of mitochondrial and metabolic proteins in ADPKD, and proposed mCAT overexpression or SS31 treatment to slow cystogenesis

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Metabolic derangement in polycystic kidney disease mouse models is ameliorated by mitochondrial-targeted antioxidants

Abstract

Extracted data

Metabolic derangement in polycystic kidney disease mouse models is ameliorated by mitochondrial-targeted antioxidants

Abstract

Extracted data

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