Comparative epigenetic analysis of tumour initiating cells and syngeneic EPSC-derived neural stem cells in glioblastoma
- Claire Vinel
- Gabriel Rosser
- Loredana Guglielmi
- Myrianni Constantinou
- Nicola Pomella
- Xinyu Zhang
- James R. Boot
- Tania A. Jones
- Thomas O. Millner
- Anaelle A. Dumas
- Vardhman Rakyan
- Jeremy Rees
- Jamie L. Thompson
- Juho Vuononvirta
- Suchita Nadkarni
- Tedani El Assan
- Natasha Aley
- Yung-Yao Lin
- Pentao Liu
- Sven Nelander
- Denise Sheer
- Catherine L. R. Merry
- Federica Marelli-Berg
- Sebastian Brandner
- Silvia Marino
Publication date
October 2021
DOI Publisher
Springer Science and Business Media LLC Journal
Nature CommunicationsAbstract
The identification of patient-specific disease mechanisms and druggable targets is crucial for precision medicine in glioblastoma. Here, the authors show that comparing patients-matched glioma-initiating cells with neural stem cells enables the discovery of patient-specific mechanisms of disease and the identification of effective drug
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