Intracellular delivery of protein drugs with an autonomously lysing bacterial system reduces tumor growth and metastases

Vishnu Raman
Nele Van Dessel
Christopher L. Hall
Victoria E. Wetherby
Samantha A. Whitney
Emily L. Kolewe
Shoshana M. K. Bloom
Abhinav Sharma
Jeanne A. Hardy
Mathieu Bollen
Aleyde Van Eynde
Neil S. Forbes

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Publication date

October 2021

DOI

10.1038/s41467-021-26367-9

Publisher

Springer Science and Business Media LLC

Journal

Nature Communications

Abstract

The limited ability of cancer therapeutics in crossing the cancer cell membrane hampers their therapeutic potential. Here, the authors report Salmonella-based system for intracellular delivery of protein drugs, e.g. caspase-3, and show reduction of tumors in mouse models of breast and liver cancer

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Intracellular delivery of protein drugs with an autonomously lysing bacterial system reduces tumor growth and metastases

Abstract

Extracted data

Intracellular delivery of protein drugs with an autonomously lysing bacterial system reduces tumor growth and metastases

Abstract

Extracted data

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