Time trends in the prevalence of infection in patients with peptic ulcer disease: a single-center retrospective study in Shanghai

Objective The present study aimed to investigate the recent trends in Helicobacter pylori infection associated with peptic ulcer disease in a large population in Shanghai. Methods We analyzed the medical records of all patients who had undergone upper gastrointestinal endoscopy (EGD) for uninvestigated dyspepsia at Ren Ji Hospital between 2013 and 2019 to determine the prevalence of H. pylori infection in patients with peptic ulcers. Results Peptic ulcers were found in 40,385 of the 383,413 patients who underwent EGD during the study period. Over the 7-year study period, the annual prevalence of H. pylori among patients receiving EGD declined from 32.2% to 26.5%. H. pylori was present in 60% of ulcers and the incidence was higher (66.9%) in duodenal compared with gastric ulcers (48.5%). The proportion of H. pylori -associated gastric ulcers declined from 52.2% to 49.3% and that of H. pylori -positive duodenal ulcers declined from 70.0% to 63.9%. Conclusion The prevalence of H. pylori- positive peptic ulcers, mainly duodenal ulcers, fell from 2013 to 2019. However, the proportion of non- H. pylori- associated peptic ulcer disease increased, especially in elderly people, possibly due to the use of nonsteroidal anti-inflammatory drugs. Further research is needed to confirm this hypothesis