Transcriptome data were collected in rat dopamine cells exposed to fipronil for 24 h using microarray analysis. Fipronil is a phenylpyrazole pesticide that acts to inhibit gamma-aminobutyric acid (GABA), blocking inhibitory synaptic transmission in the central nervous system. Transcriptome data were subjected to pathway analysis and subnetwork enrichment analysis. We report that 25 µM fipronil altered transcriptional networks in dopamine-synthesizing cells that are associated with Alzheimer's Disease, Huntington Disease, and Schizophrenia. Data analysis revealed that nerve fibre degeneration, nervous system malformations, neurofibrillary tangles, and neuroinflammation were all disease processes related to the transcriptome profile observed ...
Alzheimer's disease (AD) is the most common cause of dementia, characterized by the progressive impa...
Environmental factors, including pesticides, have been linked to autism and neurodegeneration risk u...
Extensive pesticide application has contributed to environmental contamination globally, imposing ad...
Fipronil (FPN), a widely used pesticide for agricultural and non-agricultural pest control, is possi...
Inflammatory responses are involved in mechanisms of neuronal cell damage in the pathogenesis of neu...
Experimental evidence shows that the phenylpyrazole pesticide fipronil exerts neurotoxic effects at ...
While a number of genetic mutations are associated with Parkinson's disease (PD), it is also widely ...
There are multiple lines of evidence showing that environmental toxicants including pesticides may c...
While a number of genetic mutations are associated with Parkinson's disease (PD), it is also widely ...
Fipronil (FPN) is a phenylpyrazole insecticide acted on insect gamma-aminobutyric acid (GABA) recept...
The aim of my thesis is to better characterize the neurotoxic effect of fipronil (FPN), a phenylpyra...
Pesticides entering our body, either directly or indirectly, are known to increase the risk of devel...
Fipronil (FPN) is a phenylpyrazole insecticide acted on insect gamma-aminobutyric acid (GABA) recept...
O fipronil é um inseticida fenilpirazol de amplo espectro, empregado na Medicina Veterinária e na Ag...
Alzheimer's disease (AD) is the most common cause of dementia, characterized by the progressive impa...
Alzheimer's disease (AD) is the most common cause of dementia, characterized by the progressive impa...
Environmental factors, including pesticides, have been linked to autism and neurodegeneration risk u...
Extensive pesticide application has contributed to environmental contamination globally, imposing ad...
Fipronil (FPN), a widely used pesticide for agricultural and non-agricultural pest control, is possi...
Inflammatory responses are involved in mechanisms of neuronal cell damage in the pathogenesis of neu...
Experimental evidence shows that the phenylpyrazole pesticide fipronil exerts neurotoxic effects at ...
While a number of genetic mutations are associated with Parkinson's disease (PD), it is also widely ...
There are multiple lines of evidence showing that environmental toxicants including pesticides may c...
While a number of genetic mutations are associated with Parkinson's disease (PD), it is also widely ...
Fipronil (FPN) is a phenylpyrazole insecticide acted on insect gamma-aminobutyric acid (GABA) recept...
The aim of my thesis is to better characterize the neurotoxic effect of fipronil (FPN), a phenylpyra...
Pesticides entering our body, either directly or indirectly, are known to increase the risk of devel...
Fipronil (FPN) is a phenylpyrazole insecticide acted on insect gamma-aminobutyric acid (GABA) recept...
O fipronil é um inseticida fenilpirazol de amplo espectro, empregado na Medicina Veterinária e na Ag...
Alzheimer's disease (AD) is the most common cause of dementia, characterized by the progressive impa...
Alzheimer's disease (AD) is the most common cause of dementia, characterized by the progressive impa...
Environmental factors, including pesticides, have been linked to autism and neurodegeneration risk u...
Extensive pesticide application has contributed to environmental contamination globally, imposing ad...