Multiple Organ Dysfunction Syndrome Caused by Sepsis: Risk Factor Analysis

Guo-Dong Sun,1 Yang Zhang,2 Shan-Shan Mo,3 Ming-Yan Zhao1 1Department of Critical Care Medicine, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, Heilongjiang Province, People’s Republic of China; 2Department of Nursing, Central Hospital of Heilongjiang Province Prison, Harbin, 150001, Heilongjiang Province, People’s Republic of China; 3Pharmacy Department of Heilongjiang Sailors General Hospital, Harbin, 150001, Heilongjiang Province, People’s Republic of ChinaCorrespondence: Ming-Yan Zhao Email shizhaomi0147@126.comPurpose: To analyze the risk factors of multiple organ dysfunction syndromes (MODS) caused by sepsis.Patients and Methods: A total of 180 patients with sepsis admitted to The First Affiliated Hospital of Harbin Medical University (No. 23, Post Street, Nangang District, Harbin 150001, Heilongjiang province, China) from July 2018 to June 2019 were selected and divided into a non-MODS group and a MODS group, with 90 cases in each group. Clinical data of the patients were retrospectively analyzed, and univariable and multivariable analyses were performed.Results: The univariable analysis showed that there were no significant differences in terms of age, body temperature, heart rate, respiration, mean arterial pressure, RBC specific volume, blood sodium, serum kalium, and infection site (P > 0.05). Whereas significant differences were found between the groups in terms of gender, arterial blood pH, WBC count, Apache II score, blood glucose, creatinine, chronic medical history, surgery, and ventilator usage (P < 0.05). The growth of bacterial culture, the increase of creatinine level, chronic diseases and Apache II score were discovered to have significant effects on the occurrence of MODS through the multivariable logistic regression analysis.Conclusion: Bacterial culture, serum creatinine level, history of chronic disease and Apache II score may be risk factors of MODS in sepsis patients.Keywords: sepsis, multiple organ dysfunction syndrome, risk factors, systemic inflammatory response syndrome, sepsis patients, multivariable logistic regression analysi