ALL (Acute lymphoblastic leukemia) is the most common pediatric malignancy and T-ALL (T-cell acute lymphoblastic leukemia) comprises about 15% cases. Compared with B-ALL (B-cell acute lymphoblastic leukemia), the prognosis of T-ALL is poorer, the chemotherapy is easier to fail and the relapse rate is higher. Previous studies mainly focused in Notch1-related long non-coding RNAs (lncRNAs) in T-ALL. Here, we intend to investigate lncRNAs involved in T-ALL covering different subtypes. The lncRNA PPM1A-AS was screened out for its significant up-regulation in 10 T-ALL samples of different subtypes than healthy human thymus extracts. Besides, the PPM1A-AS expression levels in 3 T-ALL cell lines are markedly higher than that in CD45+ T cells of he...
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological tumor resulting from the ...
Background: T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy of thymocytes. I...
T-cell acute lymphoblastic leukemia (T-ALL) is a rare, aggressive disease arising from T-cell precur...
SummaryNotch signaling is a key developmental pathway that is subject to frequent genetic and epigen...
Abstract Background Although some studies have demonstrated that lncRNAs are dysregulated in hematop...
Genetic studies in T-cell acute lymphoblastic leukemia have uncovered a remarkable complexity of onc...
International audienceSeveral studies have demonstrated that LncRNAs can play major roles in cancer ...
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic tumor, resulting from the t...
Background: Childhood acute lymphoblastic leukemia (ALL) explains 26% of pediatricmalignancies and i...
Abstract Background Long non-coding RNAs (lncRNAs) represent a diverse class of RNAs involved in the...
The pediatric T cell acute lymphoblastic leukemia (T-ALL) still remains a cancer with worst prognosi...
Acute lymphoblastic leukemia (ALL) is the most common cancer among children. Recent advances in chem...
The expression of both Notch3 and pre-T-cell-receptor (pre-TCR) invariant chain appears to be a comm...
Non-coding RNAs play pivotal roles in a wide variety of molecular processes. The functions of long n...
Abstract Background T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malig...
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological tumor resulting from the ...
Background: T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy of thymocytes. I...
T-cell acute lymphoblastic leukemia (T-ALL) is a rare, aggressive disease arising from T-cell precur...
SummaryNotch signaling is a key developmental pathway that is subject to frequent genetic and epigen...
Abstract Background Although some studies have demonstrated that lncRNAs are dysregulated in hematop...
Genetic studies in T-cell acute lymphoblastic leukemia have uncovered a remarkable complexity of onc...
International audienceSeveral studies have demonstrated that LncRNAs can play major roles in cancer ...
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematologic tumor, resulting from the t...
Background: Childhood acute lymphoblastic leukemia (ALL) explains 26% of pediatricmalignancies and i...
Abstract Background Long non-coding RNAs (lncRNAs) represent a diverse class of RNAs involved in the...
The pediatric T cell acute lymphoblastic leukemia (T-ALL) still remains a cancer with worst prognosi...
Acute lymphoblastic leukemia (ALL) is the most common cancer among children. Recent advances in chem...
The expression of both Notch3 and pre-T-cell-receptor (pre-TCR) invariant chain appears to be a comm...
Non-coding RNAs play pivotal roles in a wide variety of molecular processes. The functions of long n...
Abstract Background T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malig...
T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological tumor resulting from the ...
Background: T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy of thymocytes. I...
T-cell acute lymphoblastic leukemia (T-ALL) is a rare, aggressive disease arising from T-cell precur...