Predictive power of diastolic parameters on medical cardioversion success in acute atrial fibrillation

Background: Diastolic function assessment has been reported to provide valuable data in patients with atrial fibrillation (AF). The purpose of this study was to evaluate the effects of diastolic parameters on predicting the effectiveness of medical cardioversion in restoring sinus rhythm among patients with acute AF. Methods: 40 non-valvular, new onset AF patients were included. All participants received an intravenous infusion of amiodarone. In patients whom sinus rhythm could not be restored with amiodarone, an electrical cardioversion was performed. Two groups, patients who achieved sinus rhythm with amiodarone (Group-1) and who failed to achieve sinus rhythm with amiodarone (Group-2) were compared with respect to initial echocardiographic measurements. Results: Group-1 patients were younger comparing with Group-2 (mean age; 54.4 +/- 13.9 years vs 63.3 +/- 10.3 years, p = 0.028). Comparing with Group-1, Group-2 patients had; a higher left atrium volume index (17.1 +/- 4.8 cm(3)/ m(2) vs 22.6 +/- 6.6 cm(3)/ m(2), p = 0.03); a shorter pulmonary vein S (49.6 +/- 3.8 cm/sec vs 41.1 +/- 3.0 cm/sec, p < 0.001); and a shorter pulmonary vein D peak velocity (55.9 +/- 2.4 cm/sec vs 52.3 +/- 1.8 cm/sec, p < 0.001). Moreover, both IVRT and DT were significantly shorter in Group-2, comparing with Group-1 (45.1 +/- 2.1 msec vs 51.1 +/- 2.5 msec, p < 0.001 and 51.3 +/- 2.4 msec vs 56.5 +/- 3.2 msec, p < 0.001, respectively). Conclusion: The present study revealed that admission pulmonary vein S and D wave peak velocities, IVRT, DT, and Pro-BNP levels could be predictors of failure of medical cardioversion among AF patients