Advanced continuous flow strategies toward pharmaceutical ingredients

Within the context of revisiting abandoned, forbidden or forgotten chemistry and in conjunction with emerging strategies, continuous flow technology dedicated to the manufacture of high value-added molecules constitutes a significant and timely research area. While batch chemistry made it from the dawn of preparative organic chemistry to nowadays lab environments alongside with its drawbacks and benefits, continuous flow technology holds the potential to redefine the current paradigm of chemical synthesis. By overcoming the well-known boundaries of conventional chemistry, flow technology helps addressing the many aspects of chemical hazard, intensification and overall environmental footprint. This PhD dissertation intends to demonstrate the assets of continuous flow chemistry for the expedient, safe, robust and scalable preparation of active pharmaceutical ingredients and analogs