Multispectral autofluorescence lifetime imaging (maFLIM) can be used to clinically image a plurality of metabolic and biochemical autofluorescence biomarkers of oral epithelial dysplasia and cancer. This study tested the hypothesis that maFLIM-derived autofluorescence biomarkers can be used in machine-learning (ML) models to discriminate dysplastic and cancerous from healthy oral tissue. Clinical widefield maFLIM endoscopy imaging of cancerous and dysplastic oral lesions was performed at two clinical centers. Endoscopic maFLIM images from 34 patients acquired at one of the clinical centers were used to optimize ML models for automated discrimination of dysplastic and cancerous from healthy oral tissue. A computer-aided detection system was ...
Background: Several noninvasive diagnostic tools have been developed to aid the early detection of o...
Objectives: The current gold standard and more recent molecular markers in prediction of cancer ris...
Introduction: Direct tissue autofluorescence (AF) visualization devices such as VELscope® are gainin...
Although the oral cavity is easily accessible to inspection, patients with oral cancer most often pr...
Autofluorescence spectroscopy shows promising results for detection and staging of oral (pre-)malign...
Early diagnosis is critical to reducing the global burden of oral cancer. In the US, 65% of oral can...
Over the last decade, the five-year survival rate for oral cancer has remained at only 64%. Despite ...
Background and Objectives: For effective management of oral neoplasia, autofluorescence, spectroscop...
Multispectral widefield optical imaging has the potential to improve early detection of oral cancer....
A probability-based multivariate statistical algorithm combining partial least-squares (PLS) and log...
BACKGROUND: Effective detection and monitoring of potentially malignant oral lesions (PMOL) are crit...
A probability-based multivariate statistical algorithm combining partial least-squares (PLS) and log...
The diagnostic pathway for oral suspicious lesions usually starts with the clinical examination base...
Re-excision rates for breast cancer lumpectomy procedures are currently nearly 25% due to surgeons r...
Loss of autofluorescence as an early phenomenon associated with tissue degeneration seems to be prom...
Background: Several noninvasive diagnostic tools have been developed to aid the early detection of o...
Objectives: The current gold standard and more recent molecular markers in prediction of cancer ris...
Introduction: Direct tissue autofluorescence (AF) visualization devices such as VELscope® are gainin...
Although the oral cavity is easily accessible to inspection, patients with oral cancer most often pr...
Autofluorescence spectroscopy shows promising results for detection and staging of oral (pre-)malign...
Early diagnosis is critical to reducing the global burden of oral cancer. In the US, 65% of oral can...
Over the last decade, the five-year survival rate for oral cancer has remained at only 64%. Despite ...
Background and Objectives: For effective management of oral neoplasia, autofluorescence, spectroscop...
Multispectral widefield optical imaging has the potential to improve early detection of oral cancer....
A probability-based multivariate statistical algorithm combining partial least-squares (PLS) and log...
BACKGROUND: Effective detection and monitoring of potentially malignant oral lesions (PMOL) are crit...
A probability-based multivariate statistical algorithm combining partial least-squares (PLS) and log...
The diagnostic pathway for oral suspicious lesions usually starts with the clinical examination base...
Re-excision rates for breast cancer lumpectomy procedures are currently nearly 25% due to surgeons r...
Loss of autofluorescence as an early phenomenon associated with tissue degeneration seems to be prom...
Background: Several noninvasive diagnostic tools have been developed to aid the early detection of o...
Objectives: The current gold standard and more recent molecular markers in prediction of cancer ris...
Introduction: Direct tissue autofluorescence (AF) visualization devices such as VELscope® are gainin...