Astrocytes are essential cells of the central nervous system, characterized by dynamic relationships with neurons that range from functional metabolic interactions and regulation of neuronal firing activities, to the release of neurotrophic and neuroprotective factors. In Parkinson’s disease (PD), dopaminergic neurons are progressively lost during the course of the disease, but the effects of PD on astrocytes and astrocyte-to-neuron communication remain largely unknown. This study focuses on the effects of the PD-related mutation LRRK2 G2019S in astrocytes generated from patient-derived induced pluripotent stem cells. We report the alteration of extracellular vesicle (EV) biogenesis in astrocytes and identify the abnormal accumulation of ke...
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic n...
[eng] Parkinson’s disease (PD) is associated with the degeneration of ventral midbrain dopaminergic ...
Summary: Increasing evidence suggests that neurodevelopmental alterations might contribute to increa...
The principal hallmark of Parkinson’s disease (PD) is the selective neurodegeneration of dopaminergi...
Abstract In Parkinson`s disease (PD), the loss of dopaminergic (DA) neurons in the substantia nigra ...
In Parkinson's disease (PD), the loss of dopaminergic (DA) neurons in the substantia nigra pars comp...
The principal hallmark of Parkinson's disease (PD) is the selective neurodegeneration of dopaminergi...
Parkinson’s disease (PD) is a neurodegenerative, progressive disease without a cure. To prevent PD o...
Parkinson's disease (PD) is a common neurodegenerative disorder, characterised by preferential loss ...
Non-neuronal cell types such as astrocytes can contribute to Parkinson's disease (PD) pathology. The...
Non-neuronal cell types such as astrocytes can contribute to Parkinson's disease (PD) pathology. The...
Parkinson's disease (PD) is associated with the degeneration of ventral midbrain dopaminergic neuron...
Parkinson's disease (PD) is associated with the degeneration of ventral midbrain dopaminergic neuron...
Parkinson's disease (PD) is associated with the degeneration of ventral midbrain dopaminergic neuron...
Summary: Parkinson's disease (PD) is associated with the degeneration of ventral midbrain dopaminerg...
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic n...
[eng] Parkinson’s disease (PD) is associated with the degeneration of ventral midbrain dopaminergic ...
Summary: Increasing evidence suggests that neurodevelopmental alterations might contribute to increa...
The principal hallmark of Parkinson’s disease (PD) is the selective neurodegeneration of dopaminergi...
Abstract In Parkinson`s disease (PD), the loss of dopaminergic (DA) neurons in the substantia nigra ...
In Parkinson's disease (PD), the loss of dopaminergic (DA) neurons in the substantia nigra pars comp...
The principal hallmark of Parkinson's disease (PD) is the selective neurodegeneration of dopaminergi...
Parkinson’s disease (PD) is a neurodegenerative, progressive disease without a cure. To prevent PD o...
Parkinson's disease (PD) is a common neurodegenerative disorder, characterised by preferential loss ...
Non-neuronal cell types such as astrocytes can contribute to Parkinson's disease (PD) pathology. The...
Non-neuronal cell types such as astrocytes can contribute to Parkinson's disease (PD) pathology. The...
Parkinson's disease (PD) is associated with the degeneration of ventral midbrain dopaminergic neuron...
Parkinson's disease (PD) is associated with the degeneration of ventral midbrain dopaminergic neuron...
Parkinson's disease (PD) is associated with the degeneration of ventral midbrain dopaminergic neuron...
Summary: Parkinson's disease (PD) is associated with the degeneration of ventral midbrain dopaminerg...
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the loss of dopaminergic n...
[eng] Parkinson’s disease (PD) is associated with the degeneration of ventral midbrain dopaminergic ...
Summary: Increasing evidence suggests that neurodevelopmental alterations might contribute to increa...