Add to ORKGCross-reactivity and direct killing of target cells remain underexplored for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2)-specific CD8+ T cells. Isolation of T cell receptors (TCRs) and overexpression in allogeneic cells allows for extensive T cell reactivity profiling. We identify SARS-CoV-2 RNA-dependent RNA polymerase (RdRp/NSP12) as highly conserved, likely due to its critical role in the virus life cycle. We perform single-cell TCRαβ sequencing in human leukocyte antigen (HLA)-A∗02:01-restricted, RdRp-specific T cells from SARS-CoV-2-unexposed individuals. Human T cells expressing these TCRαβ constructs kill target cell lines engineered to express full-length RdRp. Three TCR constructs recognize...
Many unknowns exist about human immune responses to the severe acute respiratory syndrome coronaviru...
Coronavirus disease 2019 (COVID-19) is a global infectious disease caused by the SARS-CoV-2 coronavi...
Developing optimal T-cell response assays to severe acute respiratory syndrome coronavirus type 2 (S...
Cross-reactivity and direct killing of target cells remain underexplored for severe acute respirator...
Cross-reactivity and direct killing of target cells remain underexplored for severe acute respirator...
CD8+ T cells play an important role in vaccination and immunity against severe acute respiratory syn...
T cells are required for effective vaccination and resolution of many infections. CD4 and CD8 T cell...
In-depth understanding of human T-cell-mediated immunity in coronavirus disease 2019 (COVID-19) is n...
The data currently available on how the immune system recognises the SARS-CoV-2 virus is growing rap...
To better understand primary and recall T cell responses during coronavirus disease 2019 (COVID-19),...
The adaptive immune system provides protection against disease and maintains memory of past exposure...
To better understand primary and recall T cell responses during coronavirus disease 2019 (COVID-19),...
Effective presentation of antigens by human leukocyte antigen (HLA) class I molecules to CD8+ T cell...
To better understand primary and recall T cell responses during coronavirus disease 2019 (COVID-19),...
αβT cell receptor (TCR) genetic diversity is outnumbered by the quantity of pathogenic epitopes to b...
Many unknowns exist about human immune responses to the severe acute respiratory syndrome coronaviru...
Coronavirus disease 2019 (COVID-19) is a global infectious disease caused by the SARS-CoV-2 coronavi...
Developing optimal T-cell response assays to severe acute respiratory syndrome coronavirus type 2 (S...
Cross-reactivity and direct killing of target cells remain underexplored for severe acute respirator...
Cross-reactivity and direct killing of target cells remain underexplored for severe acute respirator...
CD8+ T cells play an important role in vaccination and immunity against severe acute respiratory syn...
T cells are required for effective vaccination and resolution of many infections. CD4 and CD8 T cell...
In-depth understanding of human T-cell-mediated immunity in coronavirus disease 2019 (COVID-19) is n...
The data currently available on how the immune system recognises the SARS-CoV-2 virus is growing rap...
To better understand primary and recall T cell responses during coronavirus disease 2019 (COVID-19),...
The adaptive immune system provides protection against disease and maintains memory of past exposure...
To better understand primary and recall T cell responses during coronavirus disease 2019 (COVID-19),...
Effective presentation of antigens by human leukocyte antigen (HLA) class I molecules to CD8+ T cell...
To better understand primary and recall T cell responses during coronavirus disease 2019 (COVID-19),...
αβT cell receptor (TCR) genetic diversity is outnumbered by the quantity of pathogenic epitopes to b...
Many unknowns exist about human immune responses to the severe acute respiratory syndrome coronaviru...
Coronavirus disease 2019 (COVID-19) is a global infectious disease caused by the SARS-CoV-2 coronavi...
Developing optimal T-cell response assays to severe acute respiratory syndrome coronavirus type 2 (S...