Beta-secretase (BACE1) and gamma-secretase activating protein (GSAP) are pivotal enzymes in the cleavage of amyloid precursor protein (APP). Beta-amyloid (A�) formation is considered one of the main reasons for Alzheimer's disease (AD) pathology. In our preliminary study, a series of microRNAs (miRs) with possible interaction with BACE1 and/or GSAP was selected using computational analysis. Our results showed that miR-4422-5p had a reduced level in the serum of AD patients. In this study, the effect of miR-4422-5p using miR-4422-5p mimic and inhibitor on BACE1 and GSAP were investigated, and a probable novel early diagnostic marker for AD was introduced. The effect of miR-4422-5p interaction with BACE1 and GSAP was evaluated via in vitro e...
A non-invasive and early-detectable peripheral biomarker is urgently needed for Alzheimer's disease ...
Generation of Amyloid peptide (Abeta) is at the beginning of a cascade that leads to Alzheimer's dis...
MicroRNAs (miRNAs) are key regulatory RNAs known to repress mRNA translation through recognition of ...
Amyloid precursor protein (APP) and beta-site amyloid precursor protein cleaving enzyme (BACE-1) pla...
MicroRNAs (miRNAs) are considered among the most reliable biomarkers to diagnose and predict Alzheim...
Alzheimer disease (AD) results, in part, from the excess accumulation of the amyloid-β (Aβ) peptide ...
Alzheimer’s disease (AD) is a common neurodegenerative disorder with progressive cognitive impairmen...
Abstract The current study investigated whether the expression of miR‐202 was abnormal in the serum ...
Indiana University-Purdue University Indianapolis (IUPUI)Alzheimer disease (AD) results, in part, fr...
Although the role of APP and PSEN genes in genetic Alzheimer's disease (AD) cases is well establishe...
Indiana University-Purdue University Indianapolis (IUPUI)Alzheimer’s disease (AD) is a progressive n...
poster abstractAlzheimer’s Disease (AD) is a neurodegenerative disorder characterized by the deposit...
Alzheimer's disease (AD) is a multifactorial, fatal neurodegenerative disorder characterized by the ...
Gene dosage effects of Amyloid precursor protein (APP) can cause familial AD. Recent evidence sugges...
Beta-secretase (BACE1) is the major enzyme participating in generation of toxic amyloid-beta (Aβ) pe...
A non-invasive and early-detectable peripheral biomarker is urgently needed for Alzheimer's disease ...
Generation of Amyloid peptide (Abeta) is at the beginning of a cascade that leads to Alzheimer's dis...
MicroRNAs (miRNAs) are key regulatory RNAs known to repress mRNA translation through recognition of ...
Amyloid precursor protein (APP) and beta-site amyloid precursor protein cleaving enzyme (BACE-1) pla...
MicroRNAs (miRNAs) are considered among the most reliable biomarkers to diagnose and predict Alzheim...
Alzheimer disease (AD) results, in part, from the excess accumulation of the amyloid-β (Aβ) peptide ...
Alzheimer’s disease (AD) is a common neurodegenerative disorder with progressive cognitive impairmen...
Abstract The current study investigated whether the expression of miR‐202 was abnormal in the serum ...
Indiana University-Purdue University Indianapolis (IUPUI)Alzheimer disease (AD) results, in part, fr...
Although the role of APP and PSEN genes in genetic Alzheimer's disease (AD) cases is well establishe...
Indiana University-Purdue University Indianapolis (IUPUI)Alzheimer’s disease (AD) is a progressive n...
poster abstractAlzheimer’s Disease (AD) is a neurodegenerative disorder characterized by the deposit...
Alzheimer's disease (AD) is a multifactorial, fatal neurodegenerative disorder characterized by the ...
Gene dosage effects of Amyloid precursor protein (APP) can cause familial AD. Recent evidence sugges...
Beta-secretase (BACE1) is the major enzyme participating in generation of toxic amyloid-beta (Aβ) pe...
A non-invasive and early-detectable peripheral biomarker is urgently needed for Alzheimer's disease ...
Generation of Amyloid peptide (Abeta) is at the beginning of a cascade that leads to Alzheimer's dis...
MicroRNAs (miRNAs) are key regulatory RNAs known to repress mRNA translation through recognition of ...