The registration contains supplementary files to the project protocol. These include the electronic search strategies and data extraction form
SPIRIT 2013 Checklist: Recommended items to address in a clinical trial protocol and related documen...
Additional file 1. Composition of the DEFINE Executive Committee and Independent Expert Panel
BACKGROUND: Early phase dose-finding (EPDF) trials are crucial for the development of a new interven...
Contains fulltext : 237212.pdf (Publisher’s version ) (Open Access)BACKGROUND: Pro...
Background: Protocols are an essential document for conducting randomised controlled trials (RCTs). ...
Additional file 2. CONSORT and SPIRIT DEFINE Literature review: Figures A2-1 – A2-2, Tables A2-1. Fi...
Background: Protocols are an essential document for conducting randomised controlled trials (RCTs). ...
Additional file 3. Organisations contacted for protocol templates or guidelines and responses
BACKGROUND:Protocols are an essential document for conducting randomised controlled trials (RCTs). H...
Patient-reported outcomes (PROs) are used in clinical trials to provide valuable evidence on the imp...
The protocol of a clinical trial serves as the foundation for study planning, conduct, reporting, an...
The protocol of a clinical trial serves as the foundation for study planning, conduct, reporting, an...
Patient-reported outcomes (PROs) are used in clinical trials to provide valuable evidence on the imp...
Additional file 10. List of candidate items to be discussed at the DEFINE Consensus meeting
INTRODUCTION: Randomised controlled trials (RCTs) may use surrogate endpoints as substitutes and pre...
SPIRIT 2013 Checklist: Recommended items to address in a clinical trial protocol and related documen...
Additional file 1. Composition of the DEFINE Executive Committee and Independent Expert Panel
BACKGROUND: Early phase dose-finding (EPDF) trials are crucial for the development of a new interven...
Contains fulltext : 237212.pdf (Publisher’s version ) (Open Access)BACKGROUND: Pro...
Background: Protocols are an essential document for conducting randomised controlled trials (RCTs). ...
Additional file 2. CONSORT and SPIRIT DEFINE Literature review: Figures A2-1 – A2-2, Tables A2-1. Fi...
Background: Protocols are an essential document for conducting randomised controlled trials (RCTs). ...
Additional file 3. Organisations contacted for protocol templates or guidelines and responses
BACKGROUND:Protocols are an essential document for conducting randomised controlled trials (RCTs). H...
Patient-reported outcomes (PROs) are used in clinical trials to provide valuable evidence on the imp...
The protocol of a clinical trial serves as the foundation for study planning, conduct, reporting, an...
The protocol of a clinical trial serves as the foundation for study planning, conduct, reporting, an...
Patient-reported outcomes (PROs) are used in clinical trials to provide valuable evidence on the imp...
Additional file 10. List of candidate items to be discussed at the DEFINE Consensus meeting
INTRODUCTION: Randomised controlled trials (RCTs) may use surrogate endpoints as substitutes and pre...
SPIRIT 2013 Checklist: Recommended items to address in a clinical trial protocol and related documen...
Additional file 1. Composition of the DEFINE Executive Committee and Independent Expert Panel
BACKGROUND: Early phase dose-finding (EPDF) trials are crucial for the development of a new interven...