This paper aimed to explain Karl Popper's philosophical foundations through comparing his ontological and epistemological principles and those outlined in the religious teachings of Islam. Popper was chosen to be studied in this paper due to a great influence of his ideas amongst experts - particularly after the Islamic Revolution of Iran – as well as owing to the considerable interest in translating his works in Iran. The methodology used in this study was analytical-deductive. The research population consisted of books, authentic papers and documents pertaining to the theoretical foundations of fundamental changes in the Islamic Republic of Iran’s formal and public education system. It was also utilized purposive sampling method. The rese...