Heart Failure (HF) is defined as the inability of the heart to efficiently pump out enough blood to maintain the body's needs, first at exercise and then also at rest. Alterations in Ca2+ handling contributes to the diminished contraction and relaxation of the failing heart. While most Ca2+ handling protein expression and/or function has been shown to be altered in many models of experimental HF, in this review, we focus in the sarcoplasmic reticulum (SR) Ca2+ release channel, the type 2 ryanodine receptor (RyR2). Various modifications of this channel inducing alterations in its function have been reported. The first was the fact that RyR2 is less responsive to activation by Ca2+ entry through the L-Type calcium channel, which is the functi...
Heart failure (HF) is a chronic multi-factorial disease characterized by sarcoplasmic reticulum (SR)...
Increased sarcoplasmic reticulum (SR) Ca2+ leak via the cardiac ryanodine receptor (RyR2) has been s...
Heart failure (HF) is a chronic multi-factorial disease characterized by sarcoplasmic reticulum (SR)...
International audienceHeart Failure (HF) is defined as the inability of the heart to efficiently pum...
International audienceHeart Failure (HF) is defined as the inability of the heart to efficiently pum...
International audienceHeart Failure (HF) is defined as the inability of the heart to efficiently pum...
Highlights • Human failing heart ryanodine receptor 2 (RyR2) Ca2+ release channels display an altere...
Highlights • Human failing heart ryanodine receptor 2 (RyR2) Ca2+ release channels display an altere...
The cardiac ryanodine receptor-Ca2+ release channel (RyR2) is an essential sarcoplasmic reticulum (S...
The cardiac ryanodine receptor-Ca2+ release channel (RyR2) is an essential sarcoplasmic reticulum (S...
The cardiac ryanodine receptor-Ca2+ release channel (RyR2) is an essential sarcoplasmic reticulum (S...
The cardiac ryanodine receptor-Ca2+ release channel (RyR2) is an essential sarcoplasmic reticulum (S...
The cardiac ryanodine receptor-Ca2+ release channel (RyR2) is an essential sarcoplasmic reticulum (S...
AbstractSarcoplasmic reticulum (SR) Ca2+ release plays an essential role in mediating cardiac myocyt...
Heart failure (HF) is a chronic multi-factorial disease characterized by sarcoplasmic reticulum (SR)...
Heart failure (HF) is a chronic multi-factorial disease characterized by sarcoplasmic reticulum (SR)...
Increased sarcoplasmic reticulum (SR) Ca2+ leak via the cardiac ryanodine receptor (RyR2) has been s...
Heart failure (HF) is a chronic multi-factorial disease characterized by sarcoplasmic reticulum (SR)...
International audienceHeart Failure (HF) is defined as the inability of the heart to efficiently pum...
International audienceHeart Failure (HF) is defined as the inability of the heart to efficiently pum...
International audienceHeart Failure (HF) is defined as the inability of the heart to efficiently pum...
Highlights • Human failing heart ryanodine receptor 2 (RyR2) Ca2+ release channels display an altere...
Highlights • Human failing heart ryanodine receptor 2 (RyR2) Ca2+ release channels display an altere...
The cardiac ryanodine receptor-Ca2+ release channel (RyR2) is an essential sarcoplasmic reticulum (S...
The cardiac ryanodine receptor-Ca2+ release channel (RyR2) is an essential sarcoplasmic reticulum (S...
The cardiac ryanodine receptor-Ca2+ release channel (RyR2) is an essential sarcoplasmic reticulum (S...
The cardiac ryanodine receptor-Ca2+ release channel (RyR2) is an essential sarcoplasmic reticulum (S...
The cardiac ryanodine receptor-Ca2+ release channel (RyR2) is an essential sarcoplasmic reticulum (S...
AbstractSarcoplasmic reticulum (SR) Ca2+ release plays an essential role in mediating cardiac myocyt...
Heart failure (HF) is a chronic multi-factorial disease characterized by sarcoplasmic reticulum (SR)...
Heart failure (HF) is a chronic multi-factorial disease characterized by sarcoplasmic reticulum (SR)...
Increased sarcoplasmic reticulum (SR) Ca2+ leak via the cardiac ryanodine receptor (RyR2) has been s...
Heart failure (HF) is a chronic multi-factorial disease characterized by sarcoplasmic reticulum (SR)...