Metabolic Acidosis and Cardiovascular Disease in CKDPlain-Language Summary
- David Collister
- Thomas W. Ferguson
- Susan E. Funk
- Nancy L. Reaven
- Vandana Mathur
- Navdeep Tangri
DOIAbstract
Rationale & Objective: Metabolic acidosis related to chronic kidney disease (CKD) is associated with an accelerated decline in glomerular filtration rate (GFR) and the development of end-stage kidney disease. Whether metabolic acidosis is associated with cardiovascular (CV) events in patients with CKD is unclear. Study Design: Retrospective cohort study. Setting & Participants: The Optum De-identified Electronic Health Records Dataset, 2007–2017, was used to generate a cohort of patients with non-dialysis-dependent CKD who had at least 3 estimated GFR < 60 mL/min/1.73 m2. Patients with metabolic acidosis (serum bicarbonate 12 to <22 mEq/L) or normal serum bicarbonate (22‒29 mEq/L) at baseline were identified by 2 consecutive measure...
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