Abstract A novel approach to de‐embed the frequency response of filters connected to a 2‐channel multiplexer without the need for unplugging is proposed. The technique to manifold coupled multiplexers with arbitrary number of filters is also theoretically generalised. In multiplexer tuning, there are practically important circumstances in which it is advantageous to de‐embed the frequency response of filters in multiplexers without detaching them. The authors show that using a novel technique and reasonable approximations, all filters of a multiplexer can be modelled by simple microwave networks, and then, the equivalent rational function of the channel filters can be estimated appropriately by the rational H2 approximation; extraction of t...