Tranexamic acid in traumatic brain injury: systematic review and meta-analysis trumps a large clinical trial?

Maas, A.I.R.
Steyerberg, E.W.
Citerio, G.

Open PDF

Open link

Publication date

October 2020

DOI

10.1007/s00134-020-06305-x.pdf

Publisher

Springer Science and Business Media LLC

Abstract

Development and application of statistical models for medical scientific researchAnalysis and support of clinical decision makin

Extracted data

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Tranexamic acid in traumatic brain injury: systematic review and meta-analysis trumps a large clinical trial?

Maas, A.I.R.
Steyerberg, E.W.
Citerio, G.

Open PDF

Open link

Publication date

October 2020

DOI

10.1007/s00134-020-06305-x.pdf

Publisher

Springer Science and Business Media LLC

Abstract

Development and application of statistical models for medical scientific researchAnalysis and support of clinical decision makin

Extracted data

Brenner A.
Belli A.
Chaudhri R.
Coats T.
Frimley L.
Jamaluddin S. F.
Jooma R.
Mansukhani R.
Sandercock P.
Shakur-Still H.
Shokunbi T.
Roberts I.
Roberts I.
Shakur-Still H.
Aeron-Thomas A.
Belli A.
Brenner A.
Chaudary M. A.
Chaudhri R.
Jamaluddin S. F. B.
Frimley L.
Javaid K.
Jooma R.
Kayani A.
Leech C.
Mahmood K.
Mansukhani R.
Noor J. M.
Mejia-Mantilla J.
Moss P.
Pott J.
Sandercock P.
Shokunbi T.
Vallecilla L.
Hartzenberg H. B.
Joshipura M.
Perel P.
Clarke M. J.
Ohaegbulam S. C.
Rodgers A.
Brady T.
Dewan Y.
Edwards P.
Komolafe E. O.
Arribas M.
Austin E.
Balogun E.
Barneston L.
Barrow C.
Beaumont D.
Benyahia M.
Brooks I.
Cargill M.
Carrington L.
Cook L.
Cornu-Hewitt B.
Geer A.
Gilbert D.
Gilliam C.
Gil-Onandia J.
Hetherington D.
Howe C.
Hughes C.
I'anson D.
Jackson R.
Joshi M.
Kansagra S.
Kawahara T.
Ker K.
Kostrov S.
Mahmood A.
Miah H.
Ndungu B.
Needham K.
Okusi C.
Outtandy A.
Pardinaz-Solis R.
Pearson D.
Pepple T.
Pisani C.
Prieto-Merino D.
Prowse D.
Quashi N.
Quinn A.
Ramos M.
Reid M.
Roukas C.
Scrapa G.
Squires C.
Tanner J.
Thayne A.
Vidaurre L.
Woods E.
Fawole B.
Adetayo O.
Okunade O.
Gogichaishvili T.
de los Angeles Munoz-Sanchez M.
Olldashi F.
Krishnan S.
Djientcheu V.
Castellanos J. L.
Rasulo F.
Hama Q.
Mulla Y.
Florian I. S.
Tobar J.
Khamis H.
Deasy C.
Wellsh B.
Williams-Johnson J.
Chandra S.
Mutiso V.
Butt R.
Nasir M. H.
Ahmad S.
Aslam F.
Ishaque K.
Usmani F.
Rizvi S.
Ali F.
Sajjad O.
Zunair A.
Rehman L.
Rizvi R.
Javeed F.
Ahmed S.
Abbas A.
Afzal A.
Mikdad A.
Bashir A.
Chaudary A.
Salahuddin T.
Ahemed B.
Aziz A.
Ashraf N.
Hussain S.
Ahmad U.
Asif M.
Adil M.
Rauf A.
Khan R.
Ahmad B.
Afzal U.
Raza H.
Ain Q.
Yaqoob S.
Waseem Q.
Nishat M.
Semvel S.
Iqbal J.
Majeed S.
Zulfiqar S.
Iqbal M.
Majeed N.
Ahmed M.
Akhtar N.
Malik M.
Shehzad Y.
Yousaf M.
Wahid A.
Samad A.
Shah S.
Ali M.
Zeb J.
Khan A. S.
Irfan A.
Sharif S.
Memon R.
Bloom B.
Harris T.
Skene I.
Bellhouse G.
Boulton O.
Ward G.
Jarvis C.
Swann C.
Ratnam S.
Carrera R.
Yakoub K.
Davies D.
Fellows E.
Jarman H.
Rounding S.
Johnson E.
Loughran C.
Lecky F.
Clayton K.
Michael A.
Coumbarides A.
Kendall J.
Faulkner B.
Worner R.
Gendall E.
Hopkins P.
Riozzi P.
Cotton H.
Astin-Chamberlain R.
Wilson M.
Bodnar J.
Williams R.
Rigoni A.
Sattout A.
Fletcher J.
Edge C.
Maryanji N.
Boyle A.
Hardwick S.
Nichols E.
Hayhurst C.
Coffey F.
Gough C.
Miller P.
Ryan L.
Darwent M.
Espinosa A.
Beer S.
Norton J.
Maguire H.
Finney K.
Kehoe A.
Squire R.
Jeffery A.
Vorwerk C.
Foord D.
Wilkinson E.
Kuhrt A.
Ramlakhan S.
Reid S.
Curran A.
McMullan S.
Hassan T.
Nuttall S.
Haig S.
Al-Nahhas S.
Bulters D.
Zolnourian A.
Ribbons T.
Mew I.
de Weymarn T.
Hughes V.
McVicar J.
McKiernan C.
Keating L.
Reschreiter H.
Wright J.
Chan L.
Kataria H.
Ireland A.
Body R.
Corfield A.
Francis S.
Townend W.
Coats T.
Gagg J.
Wilson S.
Cottingham R.
Tucker S.
Sutherland F.
Mitchell L.
Parker L.
Afolabi O.
Hunter F.
Jadav M.
Adeboye K.
Grocutt M.
May G.
Watson D.
Wootten A.
Robertshaw S.
Dorrian S.
Perry R.
Choi H.
McGroarty C.
Shone P.
Maritz D.
Jamaluddin S.
Noor J.
Rosli N.
Xian L. L. S.
De Jun Y.
Mohamed F.
Song C. H.
Hawari A.
Chin L. Y.
Hussein H. M.
Lotfi M.
Hamid H.
Udin N.
Lian P.
Choo S.
Wong K.
Gani F.
Jusoh M.
Rajakumar D.
Yang C. B.
Dzulkiflee N. S. B.
Ky W. C.
Azman M. A. B. M.
Osman A. B.
Ahmad A. H.
Ismail R.
Lai S. Q.
Mohidin M. A. B.
Deraman N. B.
Selamat S. B.
Abidin I.
Halim N.
Bakar Z.
Ismail Z. M.
Hisham B.
Kamal R.
Effendy Z.
Ismail M.
Azleen N.
Seng L. Y.
Baharuddin K. A.
Kandasamy R.
Kamalludin A.
Asmee S.
Fadzil M.
Basitz A.
Abdullah N.
Ingorokva G.
Ingorokva S.
Agdgomelashvili I.
Mumladze K.
Maisuradze I.
Kugusheva I.
Shalamberidze B.
Tomadze G.
Fernandez-Ortega J.
Seara-Valero R.
Ibanez-Botella G.
Garcia-Martinez V.
Martul M. G.
Ramos S. F.
Preciado G. L.
Garcia-Alfaro C.
Munoz-Sanchez A.
Bellido-Alba R.
Corcobado C.
Bueno A.
Ambros A.
Jimenez J. T.
Ramirez J. R.
Martin J.
Rodriguez L. I.
Fontanals J.
Jimenez-Moragas J. M.
Berbegal J. P.
Oluwole O.
Mahmud R.
Ukwu N.
Bankole F.
Oseni A.
Adebayo B.
Malomo A.
Tiamiyu L.
Adekanmbi A.
Thanni L.
Olubodun A.
Ojeblenu F.
Uwaezuoke M.
Komolafe E.
Owagbemi O.
Ishola F.
Durodola A.
Udoffa U.
James A.
Tella A.
Dongo A.
Ekpemiro U.
Anyanwu S.
Aigoro N.
Mezue W.
Shilong D.
Azeez A.
Babalola O.
Ibrahim M.
Obande J.
Franco A. C.
Salazar E. V.
Londono S. B.
Cardona V. M.
Morales C.
Naranjo S.
Agudelo J.
Carvajal S.
Fajardo-Gaviria Y.
Roka Y.
Ghising U.
Roka N.
Shrestha M.
Devkota U.
Vaidya B.
Nepal P.
Thapa A.
Kc B.
Shrestha A.
Jha R.
Shrestha P.
Hodaj I.
Spaho E.
Selaj A.
Bendo N.
Shoko T.
Endo H.
Senda A.
Hagihara Y.
Fuse T.
Masunaga N.
Otomo Y.
Egashira R.
Ohnuki T.
AlMazmi A.
Saha S.
Suvarov A.
Aung T. L.
Tun K. M.
Khaing T. T.
Maw T.
Ndome O.
Moumi M.
Mbida A.
Fondop J.
Sebastien M.
Azim A.
Adil J.
Amiry Z.
Loria-Castellanos J.
Rubio N. G.
Leon P. O.
Estrada F.
de Oca-Garcia E. M.
Sanchez H.
Soria A.
Bonucci P.
Franchi F.
Girardini A.
Hameed H.
Basim M.
Stock S.
Hourt E.
Ilunga A.
Mulenga J.
Ples H.
Danil A.
Gorgan M.
Florian I.
Vlahovic D.
French J.
East J.
Kurniawan A.
Kiboi J.

January 2020

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Amy Brenner (5351024)
Antonio Belli (3591311)
Rizwana Chaudhri (5351030)
Timothy Coats (3575405)
Lauren Frimley (9020096)
Sabariah Faizah Jamaluddin (4344367)
Rashid Jooma (2279884)
Raoul Mansukhani (9020057)
Peter Sandercock (53851)
Haleema Shakur-Still (5351027)
Temitayo Shokunbi (9625926)
Ian Roberts (27002)

November 2020

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CRASH-3 - tranexamic acid for the treatment of significant traumatic brain injury: study protocol for an international randomized, double-blind, placebo-controlled trial.

Dewan, Yashbir
Komolafe, Edward O
Mejía-Mantilla, Jorge H
Perel, Pablo
Roberts, Ian
Shakur, Haleema
CRASH-3 Collaborators

June 2012

BACKGROUND: Worldwide, over 10 million people are killed or hospitalized because of traumatic brain ...

Place of tranexamic acid in traumatic brain injury: a systematic review and meta-analysis of randomized controlled trials

Al-Jeabory, Mahdi
Szarpak, Lukasz
Rafique, Zubaid
Vasan, Nilesh R.
Attila, Kecskes
Gasecka, Aleksandra
Gawel, Wladyslaw
Pruc, Michal
Malysz, Marek
Jaguszewski, Milosz J.
Savytskyi, Ivan
Blek, Natasza
Filipiak, Krzysztof J.
Peacock, Frank W.

December 2021

BACKGROUND: Traumatic brain injury (TBI) is a leading cause of death and disability. In many cases o...

Place of tranexamic acid in traumatic brain injury: a systematic review and meta-analysis of randomized controlled trials

Al-Jeabory, Mahdi
Szarpak, Lukasz
Rafique, Zubaid
Vasan, Nilesh R.
Attila, Kecskes
Gasecka, Aleksandra
Gawel, Wladyslaw
Pruc, Michal
Malysz, Marek
Jaguszewski, Milosz J.
Savytskyi, Ivan
Blek, Natasza
Filipiak, Krzysztof J.
Peacock, Frank W.

December 2021

BACKGROUND: Traumatic brain injury (TBI) is a leading cause of death and disability. In many cases o...

Tranexamic acid for traumatic brain injury: a systematic review and meta-analysis

Zehtabchi, Shahriar
Baki, Samah G Abdel
Falzon, Louise
Nishijima, Daniel K

December 2014

ObjectiveThe antifibrinolytic agent tranexamic acid (TXA) has demonstrated clinical benefit in traum...

Tranexamic acid for significant traumatic brain injury (The CRASH-3 trial): Statistical analysis plan for an international, randomised, double-blind, placebo-controlled trial [version 2; referees: 3 approved, 1 approved with reservations]

Ian Roberts
Antonio Belli
Amy Brenner
Rizwana Chaudhri
Bukola Fawole
Tim Harris
Rashid Jooma
Abda Mahmood
Temitayo Shokunbi
Haleema Shakur
CRASH-3 trial collaborators

September 2018

Background: Worldwide, traumatic brain injury (TBI) kills or hospitalises over 10 million people eac...

Understanding the neuroprotective effect of tranexamic acid: an exploratory analysis of the CRASH-3 randomised trial.

Brenner, Amy
Belli, Antonio
Chaudhri, Rizwana
Coats, Timothy
Frimley, Lauren
Jamaluddin, Sabariah Faizah
Jooma, Rashid
Mansukhani, Raoul
Sandercock, Peter
Shakur-Still, Haleema
Shokunbi, Temitayo
Roberts, Ian
CRASH-3 trial collaborators

November 2020

BACKGROUND: The CRASH-3 trial hypothesised that timely tranexamic acid (TXA) treatment might reduce ...

Ian Roberts
Antonio Belli
Amy Brenner
Rizwana Chaudhri
Bukola Fawole
Tim Harris
Rashid Jooma
Abda Mahmood
Temitayo Shokunbi
Haleema Shakur
CRASH-3 trial collaborators

July 2018

Background: Worldwide, traumatic brain injury (TBI) kills or hospitalises over 10 million people eac...

Understanding the neuroprotective effect of tranexamic acid: an exploratory analysis of the CRASH-3 randomised trial.

Brenner, Amy
Belli, Antonio
Chaudhri, Rizwana
Coats, Timothy
Frimley, Lauren
Jamaluddin, Sabariah Faizah
Jooma, Rashid
Mansukhani, Raoul
Sandercock, Peter
Shakur-Still, Haleema
Shokunbi, Temitayo
Roberts, Ian
CRASH-3 trial collaborators

November 2020

BACKGROUND: The CRASH-3 trial hypothesised that timely tranexamic acid (TXA) treatment might reduce ...

Understanding the neuroprotective effect of tranexamic acid: an exploratory analysis of the CRASH-3 randomised trial.

Brenner, Amy
Belli, Antonio
Chaudhri, Rizwana
Coats, Timothy
Frimley, Lauren
Jamaluddin, Sabariah Faizah
Jooma, Rashid
Mansukhani, Raoul
Sandercock, Peter
Shakur-Still, Haleema
Shokunbi, Temitayo
Roberts, Ian
CRASH-3 trial collaborators

November 2020

BACKGROUND: The CRASH-3 trial hypothesised that timely tranexamic acid (TXA) treatment might reduce ...

Understanding the neuroprotective effect of tranexamic acid: an exploratory analysis of the CRASH-3 randomised trial.

Brenner, Amy
Belli, Antonio
Chaudhri, Rizwana
Coats, Timothy
Frimley, Lauren
Jamaluddin, Sabariah Faizah
Jooma, Rashid
Mansukhani, Raoul
Sandercock, Peter
Shakur-Still, Haleema
Shokunbi, Temitayo
Roberts, Ian
CRASH-3 trial collaborators

November 2020

BACKGROUND: The CRASH-3 trial hypothesised that timely tranexamic acid (TXA) treatment might reduce ...

Understanding the neuroprotective effect of tranexamic acid: an exploratory analysis of the CRASH-3 randomised trial.

Brenner, A
Belli, A
Chaudhri, R
Coats, T
Frimley, L
Jamaluddin, SF
Jooma, R
Mansukhani, R
Sandercock, P
Shakur-Still, H
Shokunbi, T
Roberts, I
CRASH-3 trial collaborators

November 2020

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Efficacy of tranexamic acid administration in traumatic brain injury patients: A review

Khaled AbdullahS Alasmari
Lena Defallah G Alzahrani
Abdulrahman Arshed N Alharfy
Aumniyat Saad A Alrashidi
Muath Sulaiman G Alhamdi
Bedour Eid H Alatawi
Faisal Saeed A Alghamdi
Sultan Suliman Q Al-Ruwaili
Amira Abdullah A Alatwi
Adnan Fahad M Soqier
Atheer Abdullah I. Al Jubeiri
Bashaier Musslum M Albalawi
Ahdab Abd Ulsattar M Alsabhi
Ibrahim Mahmoud H Ajwah
Fatimah Ali A Swead
Salem Ahmed S Shaman

March 2021

BackgroundAnti-fibrinolytic medications decrease traumatic intracranial haemorrhage (ICH). Tranexami...

Understanding the neuroprotective effect of tranexamic acid: an exploratory analysis of the CRASH-3 randomised trial

Brenner A.
Belli A.
Chaudhri R.
Coats T.
Frimley L.
Jamaluddin S. F.
Jooma R.
Mansukhani R.
Sandercock P.
Shakur-Still H.
Shokunbi T.
Roberts I.
Roberts I.
Shakur-Still H.
Aeron-Thomas A.
Belli A.
Brenner A.
Chaudary M. A.
Chaudhri R.
Jamaluddin S. F. B.
Frimley L.
Javaid K.
Jooma R.
Kayani A.
Leech C.
Mahmood K.
Mansukhani R.
Noor J. M.
Mejia-Mantilla J.
Moss P.
Pott J.
Sandercock P.
Shokunbi T.
Vallecilla L.
Hartzenberg H. B.
Joshipura M.
Perel P.
Clarke M. J.
Ohaegbulam S. C.
Rodgers A.
Brady T.
Dewan Y.
Edwards P.
Komolafe E. O.
Arribas M.
Austin E.
Balogun E.
Barneston L.
Barrow C.
Beaumont D.
Benyahia M.
Brooks I.
Cargill M.
Carrington L.
Cook L.
Cornu-Hewitt B.
Geer A.
Gilbert D.
Gilliam C.
Gil-Onandia J.
Hetherington D.
Howe C.
Hughes C.
I'anson D.
Jackson R.
Joshi M.
Kansagra S.
Kawahara T.
Ker K.
Kostrov S.
Mahmood A.
Miah H.
Ndungu B.
Needham K.
Okusi C.
Outtandy A.
Pardinaz-Solis R.
Pearson D.
Pepple T.
Pisani C.
Prieto-Merino D.
Prowse D.
Quashi N.
Quinn A.
Ramos M.
Reid M.
Roukas C.
Scrapa G.
Squires C.
Tanner J.
Thayne A.
Vidaurre L.
Woods E.
Fawole B.
Adetayo O.
Okunade O.
Gogichaishvili T.
de los Angeles Munoz-Sanchez M.
Olldashi F.
Krishnan S.
Djientcheu V.
Castellanos J. L.
Rasulo F.
Hama Q.
Mulla Y.
Florian I. S.
Tobar J.
Khamis H.
Deasy C.
Wellsh B.
Williams-Johnson J.
Chandra S.
Mutiso V.
Butt R.
Nasir M. H.
Ahmad S.
Aslam F.
Ishaque K.
Usmani F.
Rizvi S.
Ali F.
Sajjad O.
Zunair A.
Rehman L.
Rizvi R.
Javeed F.
Ahmed S.
Abbas A.
Afzal A.
Mikdad A.
Bashir A.
Chaudary A.
Salahuddin T.
Ahemed B.
Aziz A.
Ashraf N.
Hussain S.
Ahmad U.
Asif M.
Adil M.
Rauf A.
Khan R.
Ahmad B.
Afzal U.
Raza H.
Ain Q.
Yaqoob S.
Waseem Q.
Nishat M.
Semvel S.
Iqbal J.
Majeed S.
Zulfiqar S.
Iqbal M.
Majeed N.
Ahmed M.
Akhtar N.
Malik M.
Shehzad Y.
Yousaf M.
Wahid A.
Samad A.
Shah S.
Ali M.
Zeb J.
Khan A. S.
Irfan A.
Sharif S.
Memon R.
Bloom B.
Harris T.
Skene I.
Bellhouse G.
Boulton O.
Ward G.
Jarvis C.
Swann C.
Ratnam S.
Carrera R.
Yakoub K.
Davies D.
Fellows E.
Jarman H.
Rounding S.
Johnson E.
Loughran C.
Lecky F.
Clayton K.
Michael A.
Coumbarides A.
Kendall J.
Faulkner B.
Worner R.
Gendall E.
Hopkins P.
Riozzi P.
Cotton H.
Astin-Chamberlain R.
Wilson M.
Bodnar J.
Williams R.
Rigoni A.
Sattout A.
Fletcher J.
Edge C.
Maryanji N.
Boyle A.
Hardwick S.
Nichols E.
Hayhurst C.
Coffey F.
Gough C.
Miller P.
Ryan L.
Darwent M.
Espinosa A.
Beer S.
Norton J.
Maguire H.
Finney K.
Kehoe A.
Squire R.
Jeffery A.
Vorwerk C.
Foord D.
Wilkinson E.
Kuhrt A.
Ramlakhan S.
Reid S.
Curran A.
McMullan S.
Hassan T.
Nuttall S.
Haig S.
Al-Nahhas S.
Bulters D.
Zolnourian A.
Ribbons T.
Mew I.
de Weymarn T.
Hughes V.
McVicar J.
McKiernan C.
Keating L.
Reschreiter H.
Wright J.
Chan L.
Kataria H.
Ireland A.
Body R.
Corfield A.
Francis S.
Townend W.
Coats T.
Gagg J.
Wilson S.
Cottingham R.
Tucker S.
Sutherland F.
Mitchell L.
Parker L.
Afolabi O.
Hunter F.
Jadav M.
Adeboye K.
Grocutt M.
May G.
Watson D.
Wootten A.
Robertshaw S.
Dorrian S.
Perry R.
Choi H.
McGroarty C.
Shone P.
Maritz D.
Jamaluddin S.
Noor J.
Rosli N.
Xian L. L. S.
De Jun Y.
Mohamed F.
Song C. H.
Hawari A.
Chin L. Y.
Hussein H. M.
Lotfi M.
Hamid H.
Udin N.
Lian P.
Choo S.
Wong K.
Gani F.
Jusoh M.
Rajakumar D.
Yang C. B.
Dzulkiflee N. S. B.
Ky W. C.
Azman M. A. B. M.
Osman A. B.
Ahmad A. H.
Ismail R.
Lai S. Q.
Mohidin M. A. B.
Deraman N. B.
Selamat S. B.
Abidin I.
Halim N.
Bakar Z.
Ismail Z. M.
Hisham B.
Kamal R.
Effendy Z.
Ismail M.
Azleen N.
Seng L. Y.
Baharuddin K. A.
Kandasamy R.
Kamalludin A.
Asmee S.
Fadzil M.
Basitz A.
Abdullah N.
Ingorokva G.
Ingorokva S.
Agdgomelashvili I.
Mumladze K.
Maisuradze I.
Kugusheva I.
Shalamberidze B.
Tomadze G.
Fernandez-Ortega J.
Seara-Valero R.
Ibanez-Botella G.
Garcia-Martinez V.
Martul M. G.
Ramos S. F.
Preciado G. L.
Garcia-Alfaro C.
Munoz-Sanchez A.
Bellido-Alba R.
Corcobado C.
Bueno A.
Ambros A.
Jimenez J. T.
Ramirez J. R.
Martin J.
Rodriguez L. I.
Fontanals J.
Jimenez-Moragas J. M.
Berbegal J. P.
Oluwole O.
Mahmud R.
Ukwu N.
Bankole F.
Oseni A.
Adebayo B.
Malomo A.
Tiamiyu L.
Adekanmbi A.
Thanni L.
Olubodun A.
Ojeblenu F.
Uwaezuoke M.
Komolafe E.
Owagbemi O.
Ishola F.
Durodola A.
Udoffa U.
James A.
Tella A.
Dongo A.
Ekpemiro U.
Anyanwu S.
Aigoro N.
Mezue W.
Shilong D.
Azeez A.
Babalola O.
Ibrahim M.
Obande J.
Franco A. C.
Salazar E. V.
Londono S. B.
Cardona V. M.
Morales C.
Naranjo S.
Agudelo J.
Carvajal S.
Fajardo-Gaviria Y.
Roka Y.
Ghising U.
Roka N.
Shrestha M.
Devkota U.
Vaidya B.
Nepal P.
Thapa A.
Kc B.
Shrestha A.
Jha R.
Shrestha P.
Hodaj I.
Spaho E.
Selaj A.
Bendo N.
Shoko T.
Endo H.
Senda A.
Hagihara Y.
Fuse T.
Masunaga N.
Otomo Y.
Egashira R.
Ohnuki T.
AlMazmi A.
Saha S.
Suvarov A.
Aung T. L.
Tun K. M.
Khaing T. T.
Maw T.
Ndome O.
Moumi M.
Mbida A.
Fondop J.
Sebastien M.
Azim A.
Adil J.
Amiry Z.
Loria-Castellanos J.
Rubio N. G.
Leon P. O.
Estrada F.
de Oca-Garcia E. M.
Sanchez H.
Soria A.
Bonucci P.
Franchi F.
Girardini A.
Hameed H.
Basim M.
Stock S.
Hourt E.
Ilunga A.
Mulenga J.
Ples H.
Danil A.
Gorgan M.
Florian I.
Vlahovic D.
French J.
East J.
Kurniawan A.
Kiboi J.

January 2020

Background: The CRASH-3 trial hypothesised that timely tranexamic acid (TXA) treatment might reduce ...

Understanding the neuroprotective effect of tranexamic acid: an exploratory analysis of the CRASH-3 randomised trial

Amy Brenner (5351024)
Antonio Belli (3591311)
Rizwana Chaudhri (5351030)
Timothy Coats (3575405)
Lauren Frimley (9020096)
Sabariah Faizah Jamaluddin (4344367)
Rashid Jooma (2279884)
Raoul Mansukhani (9020057)
Peter Sandercock (53851)
Haleema Shakur-Still (5351027)
Temitayo Shokunbi (9625926)
Ian Roberts (27002)

November 2020

Background: The CRASH-3 trial hypothesised that timely tranexamic acid (TXA) treatment might reduce ...

CRASH-3 - tranexamic acid for the treatment of significant traumatic brain injury: study protocol for an international randomized, double-blind, placebo-controlled trial.

Dewan, Yashbir
Komolafe, Edward O
Mejía-Mantilla, Jorge H
Perel, Pablo
Roberts, Ian
Shakur, Haleema
CRASH-3 Collaborators

June 2012

BACKGROUND: Worldwide, over 10 million people are killed or hospitalized because of traumatic brain ...

Place of tranexamic acid in traumatic brain injury: a systematic review and meta-analysis of randomized controlled trials

Al-Jeabory, Mahdi
Szarpak, Lukasz
Rafique, Zubaid
Vasan, Nilesh R.
Attila, Kecskes
Gasecka, Aleksandra
Gawel, Wladyslaw
Pruc, Michal
Malysz, Marek
Jaguszewski, Milosz J.
Savytskyi, Ivan
Blek, Natasza
Filipiak, Krzysztof J.
Peacock, Frank W.

December 2021

BACKGROUND: Traumatic brain injury (TBI) is a leading cause of death and disability. In many cases o...

Place of tranexamic acid in traumatic brain injury: a systematic review and meta-analysis of randomized controlled trials

Al-Jeabory, Mahdi
Szarpak, Lukasz
Rafique, Zubaid
Vasan, Nilesh R.
Attila, Kecskes
Gasecka, Aleksandra
Gawel, Wladyslaw
Pruc, Michal
Malysz, Marek
Jaguszewski, Milosz J.
Savytskyi, Ivan
Blek, Natasza
Filipiak, Krzysztof J.
Peacock, Frank W.

December 2021

BACKGROUND: Traumatic brain injury (TBI) is a leading cause of death and disability. In many cases o...

Ian Roberts
Antonio Belli
Amy Brenner
Rizwana Chaudhri
Bukola Fawole
Tim Harris
Rashid Jooma
Abda Mahmood
Temitayo Shokunbi
Haleema Shakur
CRASH-3 trial collaborators

September 2018

Background: Worldwide, traumatic brain injury (TBI) kills or hospitalises over 10 million people eac...

Understanding the neuroprotective effect of tranexamic acid: an exploratory analysis of the CRASH-3 randomised trial.

Brenner, Amy
Belli, Antonio
Chaudhri, Rizwana
Coats, Timothy
Frimley, Lauren
Jamaluddin, Sabariah Faizah
Jooma, Rashid
Mansukhani, Raoul
Sandercock, Peter
Shakur-Still, Haleema
Shokunbi, Temitayo
Roberts, Ian
CRASH-3 trial collaborators

November 2020

BACKGROUND: The CRASH-3 trial hypothesised that timely tranexamic acid (TXA) treatment might reduce ...

Ian Roberts
Antonio Belli
Amy Brenner
Rizwana Chaudhri
Bukola Fawole
Tim Harris
Rashid Jooma
Abda Mahmood
Temitayo Shokunbi
Haleema Shakur
CRASH-3 trial collaborators

July 2018

Background: Worldwide, traumatic brain injury (TBI) kills or hospitalises over 10 million people eac...

Understanding the neuroprotective effect of tranexamic acid: an exploratory analysis of the CRASH-3 randomised trial.

Brenner, Amy
Belli, Antonio
Chaudhri, Rizwana
Coats, Timothy
Frimley, Lauren
Jamaluddin, Sabariah Faizah
Jooma, Rashid
Mansukhani, Raoul
Sandercock, Peter
Shakur-Still, Haleema
Shokunbi, Temitayo
Roberts, Ian
CRASH-3 trial collaborators

November 2020

BACKGROUND: The CRASH-3 trial hypothesised that timely tranexamic acid (TXA) treatment might reduce ...

Understanding the neuroprotective effect of tranexamic acid: an exploratory analysis of the CRASH-3 randomised trial.

Brenner, Amy
Belli, Antonio
Chaudhri, Rizwana
Coats, Timothy
Frimley, Lauren
Jamaluddin, Sabariah Faizah
Jooma, Rashid
Mansukhani, Raoul
Sandercock, Peter
Shakur-Still, Haleema
Shokunbi, Temitayo
Roberts, Ian
CRASH-3 trial collaborators

November 2020

BACKGROUND: The CRASH-3 trial hypothesised that timely tranexamic acid (TXA) treatment might reduce ...

Understanding the neuroprotective effect of tranexamic acid: an exploratory analysis of the CRASH-3 randomised trial.

Brenner, Amy
Belli, Antonio
Chaudhri, Rizwana
Coats, Timothy
Frimley, Lauren
Jamaluddin, Sabariah Faizah
Jooma, Rashid
Mansukhani, Raoul
Sandercock, Peter
Shakur-Still, Haleema
Shokunbi, Temitayo
Roberts, Ian
CRASH-3 trial collaborators

November 2020

BACKGROUND: The CRASH-3 trial hypothesised that timely tranexamic acid (TXA) treatment might reduce ...

Understanding the neuroprotective effect of tranexamic acid: an exploratory analysis of the CRASH-3 randomised trial.

Brenner, A
Belli, A
Chaudhri, R
Coats, T
Frimley, L
Jamaluddin, SF
Jooma, R
Mansukhani, R
Sandercock, P
Shakur-Still, H
Shokunbi, T
Roberts, I
CRASH-3 trial collaborators

November 2020

BACKGROUND: The CRASH-3 trial hypothesised that timely tranexamic acid (TXA) treatment might reduce ...

Efficacy of tranexamic acid administration in traumatic brain injury patients: A review

Khaled AbdullahS Alasmari
Lena Defallah G Alzahrani
Abdulrahman Arshed N Alharfy
Aumniyat Saad A Alrashidi
Muath Sulaiman G Alhamdi
Bedour Eid H Alatawi
Faisal Saeed A Alghamdi
Sultan Suliman Q Al-Ruwaili
Amira Abdullah A Alatwi
Adnan Fahad M Soqier
Atheer Abdullah I. Al Jubeiri
Bashaier Musslum M Albalawi
Ahdab Abd Ulsattar M Alsabhi
Ibrahim Mahmoud H Ajwah
Fatimah Ali A Swead
Salem Ahmed S Shaman

March 2021

BackgroundAnti-fibrinolytic medications decrease traumatic intracranial haemorrhage (ICH). Tranexami...

Understanding the neuroprotective effect of tranexamic acid: an exploratory analysis of the CRASH-3 randomised trial

Brenner A.
Belli A.
Chaudhri R.
Coats T.
Frimley L.
Jamaluddin S. F.
Jooma R.
Mansukhani R.
Sandercock P.
Shakur-Still H.
Shokunbi T.
Roberts I.
Roberts I.
Shakur-Still H.
Aeron-Thomas A.
Belli A.
Brenner A.
Chaudary M. A.
Chaudhri R.
Jamaluddin S. F. B.
Frimley L.
Javaid K.
Jooma R.
Kayani A.
Leech C.
Mahmood K.
Mansukhani R.
Noor J. M.
Mejia-Mantilla J.
Moss P.
Pott J.
Sandercock P.
Shokunbi T.
Vallecilla L.
Hartzenberg H. B.
Joshipura M.
Perel P.
Clarke M. J.
Ohaegbulam S. C.
Rodgers A.
Brady T.
Dewan Y.
Edwards P.
Komolafe E. O.
Arribas M.
Austin E.
Balogun E.
Barneston L.
Barrow C.
Beaumont D.
Benyahia M.
Brooks I.
Cargill M.
Carrington L.
Cook L.
Cornu-Hewitt B.
Geer A.
Gilbert D.
Gilliam C.
Gil-Onandia J.
Hetherington D.
Howe C.
Hughes C.
I'anson D.
Jackson R.
Joshi M.
Kansagra S.
Kawahara T.
Ker K.
Kostrov S.
Mahmood A.
Miah H.
Ndungu B.
Needham K.
Okusi C.
Outtandy A.
Pardinaz-Solis R.
Pearson D.
Pepple T.
Pisani C.
Prieto-Merino D.
Prowse D.
Quashi N.
Quinn A.
Ramos M.
Reid M.
Roukas C.
Scrapa G.
Squires C.
Tanner J.
Thayne A.
Vidaurre L.
Woods E.
Fawole B.
Adetayo O.
Okunade O.
Gogichaishvili T.
de los Angeles Munoz-Sanchez M.
Olldashi F.
Krishnan S.
Djientcheu V.
Castellanos J. L.
Rasulo F.
Hama Q.
Mulla Y.
Florian I. S.
Tobar J.
Khamis H.
Deasy C.
Wellsh B.
Williams-Johnson J.
Chandra S.
Mutiso V.
Butt R.
Nasir M. H.
Ahmad S.
Aslam F.
Ishaque K.
Usmani F.
Rizvi S.
Ali F.
Sajjad O.
Zunair A.
Rehman L.
Rizvi R.
Javeed F.
Ahmed S.
Abbas A.
Afzal A.
Mikdad A.
Bashir A.
Chaudary A.
Salahuddin T.
Ahemed B.
Aziz A.
Ashraf N.
Hussain S.
Ahmad U.
Asif M.
Adil M.
Rauf A.
Khan R.
Ahmad B.
Afzal U.
Raza H.
Ain Q.
Yaqoob S.
Waseem Q.
Nishat M.
Semvel S.
Iqbal J.
Majeed S.
Zulfiqar S.
Iqbal M.
Majeed N.
Ahmed M.
Akhtar N.
Malik M.
Shehzad Y.
Yousaf M.
Wahid A.
Samad A.
Shah S.
Ali M.
Zeb J.
Khan A. S.
Irfan A.
Sharif S.
Memon R.
Bloom B.
Harris T.
Skene I.
Bellhouse G.
Boulton O.
Ward G.
Jarvis C.
Swann C.
Ratnam S.
Carrera R.
Yakoub K.
Davies D.
Fellows E.
Jarman H.
Rounding S.
Johnson E.
Loughran C.
Lecky F.
Clayton K.
Michael A.
Coumbarides A.
Kendall J.
Faulkner B.
Worner R.
Gendall E.
Hopkins P.
Riozzi P.
Cotton H.
Astin-Chamberlain R.
Wilson M.
Bodnar J.
Williams R.
Rigoni A.
Sattout A.
Fletcher J.
Edge C.
Maryanji N.
Boyle A.
Hardwick S.
Nichols E.
Hayhurst C.
Coffey F.
Gough C.
Miller P.
Ryan L.
Darwent M.
Espinosa A.
Beer S.
Norton J.
Maguire H.
Finney K.
Kehoe A.
Squire R.
Jeffery A.
Vorwerk C.
Foord D.
Wilkinson E.
Kuhrt A.
Ramlakhan S.
Reid S.
Curran A.
McMullan S.
Hassan T.
Nuttall S.
Haig S.
Al-Nahhas S.
Bulters D.
Zolnourian A.
Ribbons T.
Mew I.
de Weymarn T.
Hughes V.
McVicar J.
McKiernan C.
Keating L.
Reschreiter H.
Wright J.
Chan L.
Kataria H.
Ireland A.
Body R.
Corfield A.
Francis S.
Townend W.
Coats T.
Gagg J.
Wilson S.
Cottingham R.
Tucker S.
Sutherland F.
Mitchell L.
Parker L.
Afolabi O.
Hunter F.
Jadav M.
Adeboye K.
Grocutt M.
May G.
Watson D.
Wootten A.
Robertshaw S.
Dorrian S.
Perry R.
Choi H.
McGroarty C.
Shone P.
Maritz D.
Jamaluddin S.
Noor J.
Rosli N.
Xian L. L. S.
De Jun Y.
Mohamed F.
Song C. H.
Hawari A.
Chin L. Y.
Hussein H. M.
Lotfi M.
Hamid H.
Udin N.
Lian P.
Choo S.
Wong K.
Gani F.
Jusoh M.
Rajakumar D.
Yang C. B.
Dzulkiflee N. S. B.
Ky W. C.
Azman M. A. B. M.
Osman A. B.
Ahmad A. H.
Ismail R.
Lai S. Q.
Mohidin M. A. B.
Deraman N. B.
Selamat S. B.
Abidin I.
Halim N.
Bakar Z.
Ismail Z. M.
Hisham B.
Kamal R.
Effendy Z.
Ismail M.
Azleen N.
Seng L. Y.
Baharuddin K. A.
Kandasamy R.
Kamalludin A.
Asmee S.
Fadzil M.
Basitz A.
Abdullah N.
Ingorokva G.
Ingorokva S.
Agdgomelashvili I.
Mumladze K.
Maisuradze I.
Kugusheva I.
Shalamberidze B.
Tomadze G.
Fernandez-Ortega J.
Seara-Valero R.
Ibanez-Botella G.
Garcia-Martinez V.
Martul M. G.
Ramos S. F.
Preciado G. L.
Garcia-Alfaro C.
Munoz-Sanchez A.
Bellido-Alba R.
Corcobado C.
Bueno A.
Ambros A.
Jimenez J. T.
Ramirez J. R.
Martin J.
Rodriguez L. I.
Fontanals J.
Jimenez-Moragas J. M.
Berbegal J. P.
Oluwole O.
Mahmud R.
Ukwu N.
Bankole F.
Oseni A.
Adebayo B.
Malomo A.
Tiamiyu L.
Adekanmbi A.
Thanni L.
Olubodun A.
Ojeblenu F.
Uwaezuoke M.
Komolafe E.
Owagbemi O.
Ishola F.
Durodola A.
Udoffa U.
James A.
Tella A.
Dongo A.
Ekpemiro U.
Anyanwu S.
Aigoro N.
Mezue W.
Shilong D.
Azeez A.
Babalola O.
Ibrahim M.
Obande J.
Franco A. C.
Salazar E. V.
Londono S. B.
Cardona V. M.
Morales C.
Naranjo S.
Agudelo J.
Carvajal S.
Fajardo-Gaviria Y.
Roka Y.
Ghising U.
Roka N.
Shrestha M.
Devkota U.
Vaidya B.
Nepal P.
Thapa A.
Kc B.
Shrestha A.
Jha R.
Shrestha P.
Hodaj I.
Spaho E.
Selaj A.
Bendo N.
Shoko T.
Endo H.
Senda A.
Hagihara Y.
Fuse T.
Masunaga N.
Otomo Y.
Egashira R.
Ohnuki T.
AlMazmi A.
Saha S.
Suvarov A.
Aung T. L.
Tun K. M.
Khaing T. T.
Maw T.
Ndome O.
Moumi M.
Mbida A.
Fondop J.
Sebastien M.
Azim A.
Adil J.
Amiry Z.
Loria-Castellanos J.
Rubio N. G.
Leon P. O.
Estrada F.
de Oca-Garcia E. M.
Sanchez H.
Soria A.
Bonucci P.
Franchi F.
Girardini A.
Hameed H.
Basim M.
Stock S.
Hourt E.
Ilunga A.
Mulenga J.
Ples H.
Danil A.
Gorgan M.
Florian I.
Vlahovic D.
French J.
East J.
Kurniawan A.
Kiboi J.

January 2020

Background: The CRASH-3 trial hypothesised that timely tranexamic acid (TXA) treatment might reduce ...

Understanding the neuroprotective effect of tranexamic acid: an exploratory analysis of the CRASH-3 randomised trial

Amy Brenner (5351024)
Antonio Belli (3591311)
Rizwana Chaudhri (5351030)
Timothy Coats (3575405)
Lauren Frimley (9020096)
Sabariah Faizah Jamaluddin (4344367)
Rashid Jooma (2279884)
Raoul Mansukhani (9020057)
Peter Sandercock (53851)
Haleema Shakur-Still (5351027)
Temitayo Shokunbi (9625926)
Ian Roberts (27002)

November 2020

Background: The CRASH-3 trial hypothesised that timely tranexamic acid (TXA) treatment might reduce ...

CRASH-3 - tranexamic acid for the treatment of significant traumatic brain injury: study protocol for an international randomized, double-blind, placebo-controlled trial.

Dewan, Yashbir
Komolafe, Edward O
Mejía-Mantilla, Jorge H
Perel, Pablo
Roberts, Ian
Shakur, Haleema
CRASH-3 Collaborators

June 2012

BACKGROUND: Worldwide, over 10 million people are killed or hospitalized because of traumatic brain ...

Tranexamic acid in traumatic brain injury: systematic review and meta-analysis trumps a large clinical trial?

Abstract

Extracted data

Tranexamic acid in traumatic brain injury: systematic review and meta-analysis trumps a large clinical trial?

Abstract

Extracted data

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