Influence of Metabolic Syndrome on Clinical Characteristics of Psoriasis

To study the clinical course of psoriasis in metabolic syndrome (MS) 93 patients with plaque psoriasis were examined. All patients were divided into 2 groups: Group I included 48 patients with psoriasis and MS and Group II included 45 patients with psoriasis without MS. The psoriasis area and severity index (PASI) was used to measure overall psoriasis severity and coverage. MS was diagnosed according to the recommendations of the International Diabetes Federation (2005). There were determined the body mass index (BMI), insulin resistance index (HOMA-IR) as well as quality of life and social adaptation of patients (DLQI). It was established that MS is accompanied by more severe clinical course of psoriasis. The indicators of skin lesions BSA and index PASI were 37.33% and 31.1% (p <0.05) higher compared to patients without MS. There was a relationship between BMI, HOMA-IR and PASI: (r = 0.34; r = 0.65, respectively, p <0.05). In patients with psoriasis and MS more pronounced reduction in psychosocial adaptation and quality of life in terms of DLQI was observed.