Some Aspects of Postoperative Hypoparathyroidism Prevention and Treatment

The objective of this work was to improve the results of surgical treatment of patients with various diseases of the thyroid gland (TG) in the aspect of postoperative hypoparathyroidism (HPT) development by new approaches to its prevention.The analysis of surgical treatment of 48 patients at the age of 12 to 78 with various pathology of the thyroid gland (TG) was conducted. The patients were treated in Ivano-Frankivsk Regional Oncology Dispensary and Ivano-Frankivsk City Central Clinical Hospital from 2013 to 2015. Depending on the postoperative period management, patients with signs of postoperative hypoparathyroidism were divided into 2 groups. The first group of patients received basic therapy during the postoperative period according to the Treatment Protocol, approved by the order of the Ministry of Health of Ukraine from 05.08.2009, No. 574. Patients of the second group received drug Cytoflavin in a dose of 10 ml by intravenous infusion into 200 ml of 0.9% NaCl solution for 7 days in addition to the basic therapy. The use of Cytoflavin during the postoperative period after thyroidectomy reduces symptoms of hypoparathyroidism (HPT) resulting in better oxygenation of the tissues of the parathyroid glands (PTG) and restoring the balance of the oxidative modification of proteins system and enzymes of the antioxidant system (OMP-AOS), which is manifested in significant antihypoxic and antioxidant effect of the drug and justifies indications for its use in this disease treatment.