The practice-led research project was developed initially at National Institute for Medical Research (NIMR), London 2004-5, selected from a national call and then funded by The Wellcome Trust Experiment Fund. The work explored the relationship between scientific and artistic approaches to self-experimentation as research. The project revisited Yves Klein’s 1958 exhibition ‘Le Vide’, in which methylene blue given to visitors turned their urine blue. This event was used to explore the moral and ethical limits of research through an approach of re-enactment which has seen re-emergence in contemporary arts discourse in recent years. After refusal from the ethics committee of NIMR to allow a clinical/cultural-trial to measure the likely effects ...